Use of a novel synthetic guided wound closure matrix for difficult to heal wounds

Introduction: There have been many cellular tissue products introduced into wound care throughout the years. Current technologies have either been very similar or have approached wounds in similar pathways along the wound healing cascade.

This has led to little innovation and progress for chronic wound healing. The new type of products "Synthetic Skin Substitutes" are notable for their nonbiologic composition that confers biocompatibility, reduction in refusal from religious beliefs, and cost benefits.

This study utilized the use of a new poly-lactic acid matrix (PLAM) that supports wound healing at all levels of the wound healing cascade. An opportunity for a product that utilizes lactate as a signaling molecule, has a beneficial pH shift from alkaline to acidic, supports angiogenic induction, and vascular integration was investigated.

Methods: A synthetic PLAM guided wound closure system built as a bimodal foam membrane structure was used for a 12-week study for patients with Diabetic, Venous, and Surgical site wounds. All wounds had been conservatively treated for four weeks without significant healing. Weekly visits of wounds included debridement in office or surgical followed by placement of the PLAM affixed with a silicone non-adherent layer followed up with the appropriate outer dressing to manage fluid. The patients were monitored weekly for reduction in wound size using a digital wound measurement system, pain scale assessment, signs and symptoms of infection, and weekly comparison for progression toward healing were noted.

Results: Wounds progressed toward closure or closed with no infections noted during the 12-week study period. Increased healing, led to reduction in inflammation and pain were observed as the wounds progressed toward closure or closed.

Discussion: The use of this synthetic PLAM guided wound closure system built as a bimodal foam membrane structure provided an opportunity to heal complex non-healing wounds. The products unique approach of a lactate molecule, pH shift or acidification of the wound bed, and physical structure acting as a matrix for wound healing noted in results. Further study is recommended to support the evolution of evidence and additional exploration for wound healing.

Disclosures: Nothing to disclose.