Case Studies of The Use Of Non-Invasive Pulsed Acoustic Cellular Expression (PACE) System Reduces Wound Area And Speeds Wound Closure In Patients Admitted At COVID 19 ICU Sets

Background: Facing the international background of pandemia new challenges inside COVID 19´s ITU services are raising in Brazil. One of the most important is the effective wound management of pression ulcers while patients are in Hospital bed, leading to Ischemia, microcirculatory dysfunction and PVD that cause decrease in blood flow, resulting in worsening of the wounds and delay in the healing process.

This is a prospective, single site, single-arm pilot case series. The goal of this study aims to determine the effects of weekly PACE (Pulsed Acoustic Cellular Expression) therapy on wound healing as measured with ruler and clinical evaluation.MethodsICU COVID-19.

This is an ongoing study, and we are presenting the early results.

After signing the informed consent form, a baseline standard assessment was performed with initial wound measurements (length, width and depth in cm) and pictures were taken prior to starting the PACE therapy. Subsequent images and measures of the wounds were taken weekly prior to each PACE treatment. The device dermaPACE system was used to deliver shockwave therapy from focused eletro-hydraulic acoustic pulses. Standard of care coverage was also used (Aquacel with Ag for 123 negative pressure vac for 456 and Hidrocoloide for 789).

Results: After receiving the early sessions (up to 3 weekly PACE sessions), all the 3 patients displayed a significant decrease of wound volume, wound area and improvement of vascularization and granulation of the tissue. 123 showed 51,5% reducing in wound area (hxw) after 3 sessions; 456 showed 63,9% reducing in wound area (hxw) after 2 sessions and789 showed 36,6% reducing in wound area (hxw) after 3 sessions. All 3 patients showed also significant reducing on depth of the wound.

Conclusion: In the author’s opinion PACE therapy offers an improved non-invasive standard of care that may start and enhance the healing cascade and speeding of wound closure since the early sessions and can be an important tool also in COVID-19 ICU sets.