Erythema Multiforme treated with Omega 3 Skin Substitute, Kerecis

37 yo female with history of well controlled erythema multiforme had a significant flare subacutely after bilateral reduction mammoplasty. Erythema multiforme is usually a self limited skin reaction associated with herpes simplex virus. Prior to the bilateral reduction mammoplasty, the patient's erythema multiforme was under medical control with antivirals and topical creams. The patient presented 10 days after the bilateral reduction mammoplasty with signs and symptoms of a systemic inflammatory response. The flare was thought to be stimulated by vicryl suture used to imbricate the breast tissue. The patient was admitted to the hospital and returned to operating room several times for debridement. Omega-3 Kerecis sheets were placed bilaterally after eradication of any non viable tissue. With outpatient oral antibiotics and local wound care, the bilateral breast wounds completely healed without a skin graft. The nipple areolar complex was completely salvaged with intact sensation and with an aesthetically acceptable result. Omega-3 Kerecis has broad indications and applicability in acute, subacute and chronic wounds. The allograft, Kerecis, has innate properties that consist of a natural 3D structure, natural molecular content, natural mechanical properties and natural molecular organizaiton that made it ideal for application in the scenario over other skin substitutes that may have exacerbation the condition. One application with outpatient local wound care allowed that patient to heal will native collagen. The omega-3, Kerecis, prevented the need for additional surgery, minimized donor sites and limited morbidity. Additional studies are needed to validate the use in other autoimmune conditions. However, this case study illustrates successful use of this skin substitute without an autoimmune response.