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Effect of P-188 Concentrated Surfactant Gel used concomitantly with an Iodinated Foam dressing for the treatment of acute and chronic wounds of varied etiologies
Introduction: Proper wound bed preparation and choice of appropriate wound dressings are vital in facilitating wound healing. One such dressing is the Poloxamer 188-containing Concentrated Surfactant Gel (P188-CSG), which promotes wound healing by maintaining a moist wound environment, promoting autolytic debridement, and enabling decreased pain during dressing changes. Another useful dressing is an iodinated foam which reduces bacterial burden within the wound dressing and can be cut to the shape of the wound.
Objective: This case series evaluated the efficacy of P188-CSG dressing applied with an iodinated foam in the treatments of wounds of varied etiologies including venous leg ulcers, pressure injuries, surgical traumatic wounds, diabetic neuropathic ulcers, non-reconstructable peripheral arterial disease, and burns.
Method: In this case series of 14 patients, application of P188-CSG on an iodinated foam dressing as the dressing carrier was initiated. All the patients were instructed to take specific adjunctive micronutrients and they wore dynamic dermal compression stockinettes for management of interstitial edema. The dressings were applied on the patients for approximately 2-3 months; wound size and pain during dressing changes were monitored. Due to the ongoing COVID-19 pandemic, clinic visits were minimized and telehealth care was provided.
Results: Ten patients had closed wounds within five visits (within six weeks). Two patients demonstrated improvement in wound bed granulation tissue development and > 86% reduction in wound surface area by visit #8. The patients experienced either “none” or “minimal” pain during dressing changes. None of the patients experienced any adverse event(s) related to the dressing management.
Conclusions: Data collected from this retrospective case series indicates that P188-CSG dressing can be used with an iodinated foam as part of a wound healing strategy. The dressings were well tolerated and the ease of application of this dressing ensured its uninterrupted use during home-based wound management.
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