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Using an Innovative 3D Electrospun Matrix as a First Line of Defense to Winning the War on Chronic Activity
Aims & Objectives: In wound healing, microbiome homeostasis supports the healthy cellular function of pro-regenerative cellular function, which is critical to the tissue regeneration and repair of wounds. Loss of microbiome homeostasis, often results in healing dysfunction manifested by chronicity and sustained/stalled inflammation.[1-5] The ability to disrupt chronic activity and restore normal healing function is the focus of this case series with an innovative 3D electrospun polymer matrix (I3DEPM). Three complex wounds were evaluated utilizing I3DEPM.
Case 1- 54 y/0 male with DM II, mild neuropathy, pedal pulses are palpable DP & PT _ bilateral, presented a left foot plantar hallux ulceration, 18 months in duration.I3DESM was initiated. Within 4 weeks, after 4 applications of I3DESM there was a 92% reduction in wound size achieved, demonstrating a consistent healing trajectory through to closure.
Case 2- 78 y/o male with DM II, neuropathy, Charcot Arthropathy presented post left foot, partial 1st ray resection, 2 months earlie. Amniotic was applied as patient had adequate blood flow however, wound healing stalled. I3ESM was introduced. By day 14 healthy granulation tissue visible with 35% reduction in wound size. Consistent healing trajectory was established achieving 92% wound reduction at Day 42. Complete closure by Day 77 after 4 applications of I3DESM.Case 3- 62 y/o male with DMII, morbid obesity presented with a right heel DFU, 3months in duration. I3DESM was introduced into treatment strategy.
By Day 7 a 17% decrease in wound volume was observed with an increase in granulation tissue and decrease in wound drainage and pain. By Day 30 a 70% reduction in wound volume was achieved with an 80% decrease in wound pain and drainage. Wound environment was more optimal to healing. Patient transitioned to umbilical cord product for closure.
References
References: 1. Capone, K.A., et al., Diversity of the human skin microbiome early in life. J Invest Dermatol, 2011. 131(10): p. 2026-32.; 2. Weyrich, L.S., et al., The skin microbiome: Associations between altered microbial communities and disease. Australas J Dermatol, 2015. 56(4): p. 268-74.; 3. Kalan, L. and E.A. Grice, Fungi in the Wound Microbiome. Adv Wound Care (New Rochelle), 2018. 7(7): p. 247-255.; 4. Kalan, L., et al., Redefining the Chronic-Wound Microbiome: Fungal Communities Are Prevalent, Dynamic, and Associated with Delayed Healing. MBio, 2016. 7(5).; 5. Cho, I. and M.J. Blaser, The human microbiome: at the interface of health and disease. Nat Rev Genet, 2012. 13(4): p. 260-70.
