Fractional Flow Reserve

Original Contribution

Validation of a New Non-Hyperemic Physiological Index: The Constant-Resistance Ratio (cRR)

03/27/2024

Chenguang Li, MD, PhD¹; Jing Wu, MS²; Jiayan Lin, BS³; Yizhe Wu, MD, PhD¹; Rende Xu, MD, PhD¹; Juying Qian, MD, PhD¹; William Kongto Hau, PhD⁴; Emanuele Barbato, MD, PhD^5,6; Nils P. Johnson, MD, MS^7,8; Barry Hennigan, MBBChBAO, BMedSci⁹; Colin Berry, MBChB, MD, PhD^9,10; Keith G. Oldroyd, MBChB, MD (Hons)⁹; Liang Song, PhD³; Junbo Ge, MD, PhD¹

Chenguang Li, MD, PhD1; Jing Wu, MS2;...

The authors aim to validate a new resting index, the constant resistance ratio (cRR), by retrospectively calculating the cRR values from raw pressure waveforms collected from the CONTRAST and VERIFY 2 studies and comparing these results with...

The authors aim to validate a...

03/27/2024

Journal of Invasive Cardiology

Original Contribution

Coronary Physiology Instantaneous Wave-Free Ratio (iFR) Derived From X-Ray Angiography Using Artificial Intelligence Deep Learning Models: A Pilot Study

02/21/2024

Miguel Nobre Menezes, MD, MSc^1,2; João Lourenço Silva, MSc^3,4; Beatriz Silva, MD^1,2; Rita Marante de Oliveira, BSc⁵; Tiago Rodrigues, MD^1,2; Arlindo L. Oliveira, PhD^3,4; Fausto J. Pinto, PhD^1,2

Miguel Nobre Menezes, MD, MSc1,2; Joã...

In this pilot study, the authors aimed to develop fully automated artificial intelligence models capable of binary instantaneous free-wave ratio (iFR) lesion classification from coronary angiography images alone, using measured invasive iFR...

In this pilot study, the authors...

02/21/2024

Journal of Invasive Cardiology

Original Contribution

iFR/FFR/IVUS Discordance and Clinical Implications: Results From the Prospective Left Main Physiology Registry

05/01/2023

Peter Kayaert, MD, PhD^1,2; Mathieu Coeman, MD³; Chadi Ghafari, MD^4,5; Benny Drieghe, MD⁶; Peter Gheeraert, MD, PhD⁶; Johan Bennett, MD, PhD^7,8; Keir McCutcheon, MD, PhD^7,8; Claudiu Ungureanu, MD⁹; Bert Vandeloo, MD¹⁰; Vincent Floré, MD, PhD¹¹; Kurt Hermans, MD¹²; Jo Dens, MD, PhD¹³; Georges Saad, MD¹⁴; Luc Janssens, MD¹⁵; Panos Xaplanteris, MD¹⁶; Yoann Bataille, MD, PhD^1,2; Oscar Semeraro, MD¹⁷; Joelle Kefer, MD^18,19; Sofie Gevaert, MD⁶; Michel De Pauw, MD⁶; Stéphane Carlier, MD^4,5; Marc J Claeys, MD, PhD^20,21; Steven Haine, MD, PhD^20,21

Peter Kayaert, MD, PhD1,2; Mathieu Co...

This study aimed to assess discordance between results instantaneous wave-free ratio, fractional flow reserve, and intravascular ultrasound in intermediate left main coronary lesions.

This study aimed to assess...

05/01/2023

Journal of Invasive Cardiology

Original Contribution

Reliability and Safety of a Side-Branch Jailed Second-Generation Optical-Pressure Guidewire in a Physiology-Guided Bifurcation-PCI In Vitro Model

08/01/2022

Vladimir Rubimbura, MD¹; Nils Johnson, MD, MS²; Marcel van’t Veer, PhD³; Julien Adjedj, MD, PhD^1,4; Stephane Fournier, MD¹; Marion Dupré, MD¹; Bernard De Bruyne, MD, PhD^1,5; Eric Eeckhout, MD, PhD¹; Olivier Muller, MD, PhD

Vladimir Rubimbura, MD1; Nils Johnso...

The treatment of a coronary bifurcation with a single stent (the provisional stenting technique) is associated with a good outcome in most cases. In the majority of cases, after provisional stenting technique, a residual significant...

The treatment of a coronary...

08/01/2022

Journal of Invasive Cardiology

Original Research

Offline Assessment of the Quantitative Flow Ratio: Is it Useful in Clinical Practice?

08/01/2022

Luciano de Moura Santos, MD^1,2; Wenderval Borges Carvalho Júnior, MD²; Marcelo Harada Ribeiro, MD¹; Maria Antonieta A.A. Medeiros Lopes, MD¹; Eduardo Freitas da Silva, PhD³; Julia Tizue Fukushima, MSc¹; Alexandre Antônio Cunha Abizaid, MD, PhD¹, Carlos M. Campos, MD, PhD^1,4

Luciano de Moura Santos, MD1,2; Wend...

Fractional flow reserve (FFR) has been established as the gold standard in the physiological assessment of coronary obstructions severity. However, the need to insert an intracoronary pressure guidewire is a factor that limits its use....

Fractional flow reserve (FFR)...

08/01/2022

Journal of Invasive Cardiology

Original Contribution

Translesional Fractional Flow Reserve is Related to Plaque Components in Coronary Artery Disease: A Study Combining Pressure Wire and NIRS-IVUS Analysis

09/01/2021

Uram Jin, MD¹; So-Yeon Choi, MD, PhD¹; Jisung Jung, MS¹; Jungil Lee, PhD²; Gary S. Mintz, MD³; Kyoung-Woo Seo, MD¹; Hyoung-Mo Yang, MD, PhD¹; Hong-Seok Lim, MD, PhD¹; Byoung-Joo Choi, MD¹; Myeong-Ho Yoon, MD, PhD¹; Joon-Han Shin, MD¹; Seung-Jea Tahk, MD, PhD¹

Uram Jin, MD1; So-Yeon Choi, MD, PhD...

The aim of this study was to evaluate the association between translesional pressure parameters (using a pressure wire) and plaque characteristics (using a combined near-infrared spectroscopy and intravascular ultrasound imaging catheter).

The aim of this study was to...

09/01/2021

Journal of Invasive Cardiology

Original Contribution

Clinical Utility of Novel Fractional Flow Reserve Pullback for Individual Lesion Contribution in Serial Disease

06/07/2021

Bhavik N. Modi, MBBS, PhD^1*; Ozan M. Demir, MBBS, MSc^1,2*; Haseeb Rahman, BMBCh, PhD¹; Matthew Ryan, MBChB, BSc¹; Sara Abou Sherif, MBBS¹; Howard Ellis, BSc¹; Antonio Colombo, MD³; Divaka Perera, MB, BChir, MD¹

Bhavik N. Modi, MBBS, PhD1*; Ozan M....

Fractional flow reserve (FFR) pullback is frequently used to assess serially diseased arteries, but has been shown to be inaccurate due to physiological interaction between individual lesions. We evaluated the clinical utility of a novel...

Fractional flow reserve (FFR)...

06/07/2021

Journal of Invasive Cardiology

Original Contribution

Percutaneous Coronary Intervention vs Medical Therapy for Coronary Lesions With Positive Fractional Flow Reserve (FFR) but Preserved Pressure-Bounded Coronary Flow Reserve (CFR): A Substudy of the Randomized Compare-Acute Trial

06/05/2021

Joost D.E. Haeck, MD, PhD¹; Marcel van’t Veer, PhD²;
Frederik M. Zimmermann, MD²; Franz-Josef Neumann, MD³;
Andreas S. Triantafyllis, MD, PhD⁴; Krischan D. Sjauw, MD, PhD¹;
Mohamed Abdel-Wahab, MD⁵; Elmir Omerovic, MD⁶;
Bianca M. Boxma-de Klerk, PhD⁷; Nico H.J. Pijls, MD, PhD²;
Gert Richardt, MD, PhD⁸; Pim A.L. Tonino, MD, PhD²;
Nils P. Johnson, MD, MS⁹; Pieter C. Smits, MD, PhD⁷

Joost D.E. Haeck, MD, PhD1; Marcel v...

We investigated the association of CFR in FFR-positive lesions with clinical outcomes when treated medically, as well as the treatment effect of PCI vs medical therapy in FFR-positive lesions and a preserved CFR.

We investigated the association...

06/05/2021

Journal of Invasive Cardiology

Original Research

High Prevalence of Asymptomatic Ischemia-Producing Coronary Stenosis in Patients With Critical Limb Ischemia: Anatomic and Functional Assessment With Coronary CT-Derived Fractional Flow Reserve (FFRCT)

03/12/2020

Dainis Krievins, MD¹; Edgars Zellans, MD¹; Andrejs Erglis, MD¹; Ligita Zvaigzne, MD¹; Aigars Lacis, MD¹; Sanda Jēgere, MD¹; Indulis Kumsars, MD¹; Gustavs Latkovskis, MD¹; Peteris Stradins, MD¹; Christopher K. Zarins, MD²

¹University of Latvia, Pauls Stradins Clinical University Hospital, Riga, Latvia; and ²HeartFlow, Inc., Redwood City, California

Dainis Krievins, MD1; Edgars Zellans,...

CLI patients with no cardiac history undergoing limb salvage surgery have a high prevalence of asymptomatic ischemia-producing coronary stenosis, which may put them at increased risk.

CLI patients with no cardiac...

03/12/2020

Vascular Disease Management

Clinical Editor's Corner

Is the FAME Approach to CAD in TAVI Patients Applicable?

12/30/2019

Morton Kern, MD, MSCAI, FACC, FAHA

Clinical Editor; Chief of Medicine, Long Beach VA Medical Center, Long Beach, California;

Associate Chief Cardiology, University of California, Irvine Medical Center, Orange, California

Morton Kern, MD, MSCAI, FACC, FAHA C...

At this time, I believe we should use functional (FFR/NHPR) assessment of CAD for best decisions in this often elderly and frail patient group.

At this time, I believe we...