Abstracts

Fluoropyrimidine- and irinotecan-induced toxicity profile associated with mutations in DPYD and UGT1A1 genes

Background Fluoropyrimidines are a mainstay in the treatment of gastrointestinal tumours (GIT), although they can sometimes produce severe toxicity, usually related to p...

Brage E. Terán ;

Tocino R. Vidal ;

García B. Cigarral ;

Sánchez E. Fonseca ;

Martín M. Navarro ;

Jung D. Heredero ;

Berrocal B. García ;

Jiménez M. Navalón ;

06/27/2022

Transgelin/PARP1 regulates colorectal cancer metastasis through Rho GTPase pathway

Background Our previous studies showed that transgelin may promoted the migration of HT29 and HCT116 colon cancer cells through nuclear translocation. Proteomics analysi...

Z. Ye ;

Y. Lin ;

06/27/2022

Variant detection and personalized treatment in colorectal cancer

Background Colorectal cancer, a type of malignancy in the colon or rectum, constitutes one of the most prevalent types of cancer, with high mortality rate. There are ava...

06/27/2022

The Geriatric 8 score is associated with risk of hospitalisation and 6-month survival in patients with incurable pancreatic cancer receiving gemcitabine and capecitabine

Background Assessing frailty in cancer patients can aid treatment decisions, target geriatric interventions and improve outcomes. The G8 score is a screening tool to det...

06/27/2022

Ampullary neoplasms – how to treat in real-world practice? A retrospective study

Background Ampullary carcinomas are rare malignant tumours, originating at the complex of the ampulla of Vater. Surgery is the only potentially curative treatment and pr...

06/27/2022

Cytoreductive surgery in patients with metastatic gastrointestinal stromal tumors sensitive to imatinib: A retrospective analysis of 2 Russian cancer centers

Background The role of cytoreductive surgery for patients with metastatic gastrointestinal stromal tumors (mGIST) responding to imatinib (IM) has not been established ye...

Lyudmila Zhukova ;

Petr Arkhiri ;

Maksim Nikulin ;

Igor Sagaidak ;

Vladimir Yugay ;

Andrey Meshcheryakov ;

Daria Filonenko ;

06/27/2022

Anti-EGFR antibodies may get benefit as first-line treatment in metastatic right-sided colon cancer

Background Location of the primary tumor can be prognostic and predictive of response to EGFR inhibitors as first-line treatment in mCRC suggesting that cetuximab and pa...

06/27/2022

DPYD evaluation and dose adjustment in patients with gastrointestinal cancer before initiation of fluoropyrimidine-based chemotherapy: One-centre experience

Background Fluoropyrimidines (FP) are the mainstay treatment of many neoplasms, especially the gastrointestinal (GI) tract cancers. Its metabolism is guaranteed by the e...

06/27/2022

Hepatocellular carcinoma: 9 years of experience in the medical oncology department at Mohammed VI University Hospital in Marrakech, Morocco

Background Hepatocellular carcinoma (HCC) is a primary malignant tumor of the liver, which remains asymptomatic for a long time. Diagnosis is most often late and its 5-y...

06/27/2022

Circulating tumor cell enumeration, biomarker analyses, and kinetics in patients with colorectal cancer and other GI malignancies

Background “Liquid biopsies” are revolutionizing cancer care. The broad term often refers to identification of circulating tumor DNA (ctDNA) and circulating tumor cells ...

Pashtoon Murtaza Kasi ;

Walla Malkawi ;

Aliasger K. Salem ;

06/27/2022