Maria Wieman, MPH

Development of Deutetrabenazine as a Potential New Non-Antipsychotic Treatment for Tourette Syndrome in Children and Adolescents

Background: Tourette syndrome (TS) is a neurodevelopmental disorder characterized by the hyperkinetic movements of motor and phonic tics manifested in young age. Currently approved treatm...

Joseph Jankovic , MD;

Maria Wieman , MPH;

Barbara Coffey , MD, MS;

David Stamler , MD;

Daniel Claassen , MD;

Barry Gertz , MD, PhD;

Elisabeth Garofalo , MD;

Juha-Matti Savola , MD, PhD;

Mark Forrest Gordon , MD;

11/22/2019

Randomized Withdrawal Study Design to Evaluate the Persistence of the Therapeutic Effect of Deutetrabenazine in the Treatment of Tardive Dyskinesia

Background: The long-term open-label extension study of rollover subjects (n=343) from the ARM-TD and AIM-TD trials evaluating the safety and efficacy of deutetrabenazine for the treatmen...

Karen Anderson , MD;

Hubert Fernandez , MD;

Hadas Barkay , PhD;

Juha-Matti Savola , MD, PhD;

Mark Forrest Gordon , MD;

Maria Wieman , MPH;

Mat Davis , PhD;

Leslie Marinelli , BS;

11/22/2019

Analysis of AIMS Global Judgment Components (Items 8–10) in Patients With TD: Results From the ARM-TD and AIM-TD Studies

Background: Tardive dyskinesia (TD) is a debilitating, often-irreversible hyperkinetic movement disorder that impairs patients’ abilities to perform daily activities. Deutetrabenazine was...

Amanda Wilhelm , PhD;

Hadas Barkay , PhD;

Rolf T. Hansen , PhD;

Juha-Matti Savola , MD, PhD;

Maria Wieman , MPH;

Nicholas Gross , MS;

11/22/2019

Effect of Deutetrabenazine on Metabolic Parameters in the Treatment of Tardive Dyskinesia

BACKGROUND: Deutetrabenazine, a novel vesicular monoamine transporter 2 (VMAT2) inhibitor, is approved by the FDA for treatment of tardive dyskinesia (TD) in adults. Dopamine-receptor ant...

Maria Wieman , MPH;

Robert G. Hauser , MD, MBA, PhD;

Joohi Jimenez-Shahed , MD;

Karen Anderson , MD;

Hubert Fernandez , MD;

Hadas Barkay , PhD;

Juha-Matti Savola , MD, PhD;

Mark Forrest Gordon , MD;

Stewart Factor , DO;

11/22/2019