Gillian Anderson

Effect of Lemborexant Treatment in Older Adults with Insomnia and Objective Short Sleep Duration as Assessed by Polysomnographic Sleep Measures

Abstract: Introduction: There is evidence that insomnia patients with objective short-sleep duration (I-SSD; total sleep time [TST]

Elizabeth Pappadopulos ;

Gillian Anderson ;

01/19/2023

Subjects with Insomnia Disorder and Comorbid Pain at Baseline: Response to Lemborexant

Abstract: Introduction: There is a well-established reciprocal relationship between pain and poor sleep. Therefore, it is clinically important to evaluate whether a sleep-promoting drug s...

Elizabeth Pappadopulos ;

Gillian Anderson ;

01/19/2023

Pattern of Reports of Headache in Phase 3 Clinical Trials of Lemborexant

Abstract: Introduction: Headache is a frequently reported treatment-emergent adverse event (TEAE) in clinical trials of hypnotics. We evaluated the frequency and timing of TEAEs of headac...

Gillian Anderson ;

Christie Lundwall ;

01/19/2023

Relationship Between Daytime Functioning and Fatigue Over 6 Months in Lemborexant-Treated Subjects with Insomnia Disorder

Abstract: Introduction: Study E2006-G000-303 (Study 303; NCT02952820) showed lemborexant (LEM) provided significant benefit vs placebo (PBO) on patient-reported sleep and fatigue severity...

Gillian Anderson ;

Christie Lundwall ;

01/19/2023

Subjective Ratings of Medication Strength of Lemborexant Over 6 Months in Subjects With Moderate or Severe Insomnia

Abstract: Introduction: A concern with sedative-hypnotic medication for the treatment of insomnia is the development of tolerance. The Patient Global Impression–Insomnia (PGI-I) and Insom...

Margaret Moline , PhD;

Gillian Anderson ;

01/19/2023

The Incidence of Abnormal Dreams and Nightmares in Adults With Insomnia Treated With Lemborexant: Results From Two Phase 3 Studies

Abstract: Introduction: Abnormal dreams and nightmares are reported by patients with insomnia both before and after treatment with hypnotics. Dual orexin receptor antagonists such as lemb...

Margaret Moline , PhD;

Gillian Anderson ;

01/19/2023