Ann-Lii Cheng, MD, PhD

Durvalumab with or without Bevacizumab as Adjuvant Therapy for Patients with Hepatocellular Carcinoma at Risk of Recurrence After Curative Therapy: EMERALD-2

Purpose: Hepatic resection and ablation are standard of care for patients with hepatocellular carcinoma (HCC), but although potentially curative, the risk of recurrence is high (44%–79% a...

Joong-Won Park ;

Peter R. Galle , MD, PhD;

Riccardo Lencioni , MD;

Jennifer J. Knox ;

Jiaqi Fan , MD;

Ann-Lii Cheng , MD, PhD;

Shethah Morgan ;

Jian Zhou , MD, PhD;

Sean Cleary ;

Norihiro Kokudo ;

10/21/2019

Pembrolizumab (Pembro) therapy vs best supportive care (BSC) in advanced hepatocellular carcinoma (HCC): KEYNOTE-240

BackgroundPembro received accelerated approval for second-line therapy in pts with advanced HCC, based on the phase 2, KEYNOTE-224 trial. KEYNOTE-240 was a randomized, phase 3 study of P...

Marcelo Garrido ;

Stephen Lam Chan , MD;

Jennifer J. Knox ;

Bruno Daniele ;

Scot Ebbinghaus ;

Erluo Chen ;

Abby B. Siegel ;

Julien Edeline ;

Baek-Yeol Ryoo ;

Ann-Lii Cheng , MD, PhD;

Philippe Merle ;

Masatoshi Kudo , MD, PhD;

Mohamed Bouattour ;

Richard S. Finn ;

Ho-Yeong Lim ;

Andrew Zhu ;

Valeriy Vladimirovich Breder , MD, PhD;

Yee Chao ;

Sadahisa Ogasawara ;

Thomas Yau ;

07/01/2019

CIO 2020-22 Durvalumab±Bevacizumab As Adjuvant Therapy In HCC At Risk Of Recurrence After Curative Therapy: EMERALD-2

Peter R. Galle , MD, PhD;

Riccardo Lencioni , MD;

Philip He ;

Jennifer J. Knox ;

Shethah Morgan ;

Jiaqi Fan , MD;

Gordon Cohen ;

Sean Cleary ;

Ann-Lii Cheng , MD, PhD;

Norihiro Kokudo ;

Jian Zhou , MD, PhD;

Joong-Won Park ;

07/23/2021

CIO 2023-13 IMbrave050: Phase 3 study of adjuvant atezolizumab + bevacizumab vs surveillance in hepatocellular carcinoma patients

Purpose: The risk of HCC recurrence after liver resection or ablation with curative intent is 70-80% within 5 years, indicating an unmet need for effective adjuvant therapies. Atezolizuma...

Jeong Heo , MD, PhD;

David Hsieh , MD;

Masatoshi Kudo , MD, PhD;

Han Chu Lee , MD, PhD;

Qinshu Lian , PhD;

Shinichiro Nakamura , MD, PhD;

Kazushi Numata , MD;

Shukui Qin , MD, PhD;

Jessica Spahn , PhD;

Won Young Tak , MD, PhD;

Thomas Uguen , MD;

Edward Cha , PhD;