Heather Tyldesley

Different in Vitro Wound Models for Studying Cell Salvage Effects of Concentrated Surfactant Gels

Background: Cell membrane damage is common in skin injury. Cell survival depends on the initiation of a rapid resealing to resume the structural integrity of the cell membrane to mai...

Rui Chen , PhD;

Heather Tyldesley ;

Steven L. Percival , PhD;

Anne-Marie Salisbury , PhD;

Marc Mullin , BSc;

08/12/2019

In Vitro Inflammatory Response in Macrophages by Concentrated Surfactant Based Wound Dressings

Background: Despite inflammation playing an important role in the early stages of wound healing to help clear out damaged and dead cells along with microrganisms or foreign debris th...

Rui Chen , PhD;

Heather Tyldesley ;

Steven L. Percival , PhD;

Anne-Marie Salisbury , PhD;

Marc Mullin , BSc;

08/12/2019

Ability of a Concentrated Surfactant Wound Gel Containing PHMB to Prevent Biofilm Formation

Background: Biofilms are formed when microbial cells adhere to a surface and each other and secrete extracellular polymeric substance (EPS), encasing themselves in a matrix. There is...

Heather Tyldesley ;

Rui Chen , PhD;

Steven L. Percival , PhD;

Anne-Marie Salisbury , PhD;

Marc Mullin , BSc;

08/12/2019

Bacterial Silver Resistance Following Repeated Serial Passage and Cross Resistance to Antimicrobials and Antibiotics

Background: The rise in multidrug resistant (MDR) infections is a global concern. Whilst there is relatively less evidence of silver resistance compared to antibiotic resistance, sil...

Heather Tyldesley ;

Rui Chen , PhD;

Steven L. Percival , PhD;

Anne-Marie Salisbury , PhD;

Marc Mullin , BSc;

07/31/2019

Debridement Efficiency of Wound Gels by an in vitro Artificial Wound Eschar Model

In this study, a newly designed fluorescent artificial wound eschar (fAWE) model applied to examine efficacy of wound dressing gels on eschar debridement with/without enzymes was develope...

Rui Chen , PhD;

Steven L. Percival , PhD;

Heather Tyldesley ;

Anne-Marie Salisbury , PhD;

Marc Mullin , BSc;

07/31/2019

Next Generation Antibiofilm EDTA Metal Complexes and in Vitro Cytotoxicity

Background: In this study, we synthesized ten EDTA patent pending complexes with different concentrations of metals and we also examined the cytotoxicity of EDTA complexes compared t...

Steven L. Percival , PhD;

Anne-Marie Salisbury , PhD;

Marc Mullin , BSc;

Heather Tyldesley ;

Rui Chen , PhD;

Stephen Law , PhD;

07/31/2019

EDTA Complexes with Metal Ions Demonstrate Outstanding Synergism for Antibiofilm Efficacy Against Wound Pathogens

Background: There is increasing evidence showing the presence of biofilms on surfaces, such as wounds, leading to infection, inflammation and delayed wound healing. Microbes growing ...

Steven L. Percival , PhD;

Anne-Marie Salisbury , PhD;

Marc Mullin , BSc;

Heather Tyldesley ;

Rui Chen , PhD;

Stephen Law , PhD;

07/31/2019

In Vitro Cell Plasma Membrane Resealing Model to Study Cell Salvage Effect of Concentrated Surfactant Gels

Background: For wound healing and tissue reparation/regeneration after skin injury, it is important to rapidly reseal ruptured cell plasma membrane and resume the structural integrit...

Rui Chen , PhD;

Heather Tyldesley ;

Steven L. Percival , PhD;

Anne-Marie Salisbury , PhD;

Marc Mullin , BSc;

07/31/2019

Treatment of Candida Albicans and Trichophyton Rubrum with Several Antimicrobial Agents Using a Fungal Nail Model

Background: Onychomycosis is a nail infection that can be caused by dermatophyte fungi including Candida albicans and Trichophyton rubrum. Onychomycosis can cause nail discolouration...

Heather Tyldesley ;

Rui Chen , PhD;

Steven L. Percival , PhD;

Anne-Marie Salisbury , PhD;

Marc Mullin , BSc;

07/29/2019

Evaluation of Antimicrobial Agents Against Biofilms Grown in the Drip Flow Bioreactor Using Different Models

Background: Biofilms are formed when microbial cells adhere to a surface, and each other, and secrete extracellular polymeric substance (EPS), encasing themselves in a matrix. Biofil...

Anne-Marie Salisbury , PhD;

Marc Mullin , BSc;

Heather Tyldesley ;

Rui Chen , PhD;

Steven L. Percival , PhD;

07/29/2019