ABSTRACT Background: Surgical Site Infection (SSI) rates for post-op Open Reduction Internal Fixation (ORIF) tibia/fibula fractures range from 13-88%. Post-op infection has been associate...
Introduction: Chronic wounds fail to heal due to a variety of systemic and local factors including high microbial burden and excessive devitalized tissue. Healing becomes compromised once...
IntroductionDebridement represents a key step in the management of chronic wounds and is considered a basic necessity to induce tissue repair. Biofilm infection in wounds is a major contr...
Introduction: Traumatic injuries can lead to massive, complex wounds with an increased propensity for infection. Despite the prevalence of patients with such wounds presenting at level 1 ...
Introduction: Chronic wounds affect 6.5 million people in the US. [1]. They contribute significantly to lower limb amputations. Every 20 seconds a limb is amputated somewhere in the world...
Introduction: Diabetes mellitus (DM) has the potential to significantly decrease quality of life due to its complications, including but not limited to diabetic foot ulcers and possible a...
Introduction: The application of multi-layer compression therapy is the gold standard for the management of patients with venous insufficiency and other wounds compromised by lower extre...
Introduction: Chronic venous insufficiency is the 7th most common chronic disease and is the underlying cause of 95% of leg ulcers1. Venous leg ulcers (VLUs) are difficult to treat and ev...
Introduction: A majority of chronic wounds are plagued by the formation of adherent biofilm. Biofilm develops when colonies of surface-attached bacteria form connections and exude a prote...
Introduction: Keratin is a fibrous structural protein that provides mechanical stability to cells of the epidermis. Recent advances have been made in understanding the role of keratin in ...