Lower Extremity Wounds

Rheological Characterization of 3D Printed Adipose Grafts for Wound Healing

Introduction: A revolutionary advance in personalized wound care uses a patient's own adipose tissue as the foundation for creating custom-designed wound tissue grafts with the Aplicor 3D...

11/01/2024

Utilization of Near Infrared Spectroscopy* in Peripheral Arterial Disease and Angiosome Correlation

Introduction: Near Infrared Spectroscopy* (NIRS) is a non-invasive imaging device that measures oxygenated and deoxygenated hemoglobin in the wound and periwound tissues to assess the tis...

11/01/2024

Induction of Diabetic Ulcers through Collagen Glycosylation

Introduction: Diabetic ulcers are a significant complication of diabetes mellitus, commonly attributed to peripheral neuropathy and associated vascular insufficiencies. However, this rev...

11/01/2024

Crosslinked Native Collagen Matrices Containing Polyhexamethylene Biguanide (PHMB) Modulate Matrix Metalloproteinases, Function as Scaffold for Cell Growth, and Inhibit Bacterial Growth In Vitro and In Vivo

Introduction: Collagen-based wound matrices are widely used for treating acute and chronic wounds due to their role in wound management. The addition of an antimicrobial to these matrices...

11/01/2024

Effect of Different Processing Methods on Biomarker Libraries of Minimally Manipulated Autologous Human Adipose Grafts

Introduction: Aplicor 3D is a novel FDA-cleared 3D printer that uses autologous human adipose to create patient-specific wound coverings. Solidifying the soft adipose tissue into a graft ...

11/01/2024

Harnessing the power of our immune system: antibiofilm effects of action of nitric oxide

Introduction: Hard-to-heal wounds pose a significant clinical challenge, resulting in poor patient quality of life and substantial economic burden. Polymicrobial communities within hard-t...

11/01/2024

The cell migration effects of decellularized porcine placental extracellular matrix in viable wounded human skin ex vivo

Introduction: Decellularized extracellular matrix (ECM) medical devices can facilitate healing of hard-to-heal wounds by acting as a scaffold. A novel decellularized porcine placental ECM...

11/01/2024

Quantified Wound Healing Dynamics Stimulated By Therapeutic Oat Bioactives

Introduction: Our previous studies have shown that oat-derived bioactives avenanthramide (AVE) and beta-glucan (βG) stimulate endothelial proliferation in vitro, angiogenesis and endothe...

11/01/2024

Tri-Layer Amniotic Membrane Allografts promotes re-epithelialization in vitro via cJUN mediated mechanism

Introduction: Wound re-epithelialization is marked by the formation of a new epithelial layer that re-establishes the barrier between a wound and the environment allowing for successful w...

11/01/2024

Improving Proficiency in Wound and Ostomy Care: A Practical Training Program for Recently Graduated Registered Nurses

Introduction: Background: Professional wound and ostomy care is necessary in to enhance outcomes and quality of life for patients who require it. Newly certified registered nurses (RNs) o...

11/01/2024