Sepsis Episodes Caused by Pressure Injuries in Critical Illness: A Retrospective Observational Cohort Study

1. Labeau SO, Afonso E, Benbenishty J, et al. Prevalence, associated factors and outcomes of pressure injuries in adult intensivecare unit patients: the DecubICUs study [published correction appears in Intensive Care Med. 2021;47(4):503-520]. Intensive Care Med. 2021;47(2):160-169. doi:10.1007/s00134-020-06234-9

2. Jugun K, Richard JC, Lipsky BA, et al. Factors associated with treatment failure of infected pressure sores. Ann Surg. 2016;264(2):399-403. doi:10.1097/SLA.0000000000001497

3. Mayr FB, Yende S, Angus DC. Epidemiology of severe sepsis. Virulence. 2014;5(1):4-11. doi:10.4161/viru.27372

4. Gomes F, Furtado GE, Henriques M, et al. The skin microbiome of infected pressure ulcers: a review and implications for health professionals. Eur J Clin Invest. 2022;52(1):e13688. doi:10.1111/eci.13688

5. Vincent JL, Sakr Y, Singer M, et al. Prevalence and outcomes of infection among patients in intensive care units in 2017. JAMA. 2020;323(15):1478-1487. doi:10.1001/jama.2020.2717

6. Badia M, Serviá L, Casanova JM, et al. Classification of dermatological disorders in critical care patients: a prospective obsrvational study. J Crit Care. 2013;28(2):220.e1-e8. doi:10.1016/j.jcrc.2012.06.006

7. Livesley NJ, Chow AW. Infected pressure ulcers in elderly individiduals. Clin Infect Dis. 2002;35(11):1390-1396. doi:10.1086/344059

8. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/ SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101(6):1644–1655. doi:10.1378/chest.101.6.1644

9. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med. 2003;29(4):530–538. doi:10.1007/s00134-003-1662-x

10. Calandra T, Cohen J, International Sepsis Forum Definition of Infection in the ICU Consensus Conference. The International Sepsis Forum consensus conference on definitions of infection in the intensive care unit. Crit Care Med. 2005;33(7):1538-1548. doi:10.1097/01.ccm.0000168253.91200.83

11. KDIGO guidelines. Available at: https://kdigo.org/guidelines/acute-kidney-injury/. Accessed July 10, 2022.

12. Infectious complications of pressure-induced skin and soft tissue injury. Available at https://www.uptodate.com/contents/infectious-complications-of-pressure-induced-skin-and-soft-tissue-injury. Accessed July 16, 2022.

13. Dana AN, Bauman WA. Bacteriology of pressure ulcers in individuals with spinal cord injury: what we know and what we should know. J Spinal Cord Med. 2015;38(2):147-160. doi:10.1179/2045772314Y.0000000234

14. Espejo E, Andrés M, Borallo RM, et al. Bacteremia associated with pressure ulcers: a prospective cohort study. Eur J Clin Microbial Infect Dis. 2018;37(5):969-975. doi:10.1007/s10096-018-3216-8

15. Wall BM, Mangold T, Huch KM, Corbett C, Cooke CR. Bacteremia in the chronic spinal cord injury population: risk factors for mortality. J Spinal Cord Med. 2003;26(3):248-253. doi:10.1080/10790268.2003.11753692

16. Nicastri E,Viale P, Lyder CH, et al. Incidence and risk factors associated with pressure ulcers among patients with HIV infection. Adv Skin Wound Care. 2004;17(5 Pt 1):226-231. doi:10.1097/00129334-200406000-00011

17. Serra R, Grande R, Buffone G, et al. Albumin administration prevents the onset of pressure ulcers in intensive care unit patients. Int Wound J. 2015;12(4):432-435. doi:10.1111/iwj.12131

18. Joannidis M, Wiedermann CJ, Ostermann M. Ten myths about albumin. Intensive Care Med. 2022;48(5):602-605. doi:10.1007/s00134-022-06655-8 [Erratum in Correction: Ten myths about albumin. Joannidis M, Wiedermann CJ, Ostermann M. Intensive Care Med. 2022;48(6):793. doi:10.1007/s00134-022-06680-7]

19. Byrd AL, Belkaid Y, Serge JA. The human skin microbiome. Nat Rev Microbiol. 2018;16(3):143-155. doi:10.1038/nrmicro.2017.157

20. Bhattacharya S, Misha RK. Pressure ulcers: current understanding and newer modalities of treatment. Indian J Plast Surg. 2015;48(1):4-16. doi:10.4103/0970-0358.155260

21. Moura J, Madureira P, Leal EC, Fonseca AC, Carvalho E. Immune aging in diabetes and its implications in wound healing. Clin Immunol. 2019;200:43-54. doi:10.1016/j.clim.2019.02.002

22. Jaul E, Barron J, Rosenzweig JP, Menczel J. An overwiew of co-morbidities and the development of pressure ulcers among older adults. BMC Geriatr. 2018;18(1):305. doi:10.1186/s12877-018-0997-7

23. Garg AX, Blake PG, Clark WF, Clase CM, Haynes RB, Moist LM. Association between renal insufficiency and malnutrition in older adults: results from NHANES III. Kidney Int. 2001;60(5):1867-1874. doi:10.1046/j.1523-1755.2001.00001.x

24. Sproston NR, Ashworth JJ. Role of C-reactive protein at sites of inflammation and infection. Front Immunol. 2018;9:754. doi:10.3389/fimmu.2018.00754