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Understanding the Role of BTK in Cancer Pathogenesis
Transcript:
Most B-cell development begins in the bone marrow and involves several pathways to ensure accurate B-cell proliferation and maturation. Bruton's tyrosine kinase, or BTK, is a non-receptor tyrosine kinase downstream of the B-cell receptor, and an essential component in B-cell maturation. When correctly formed and functional, B-cell receptors are activated via antigen binding and perpetuate downstream signaling. BTK is recruited to the membrane for activation and in turn initiates signal cascades necessary for B-cell proliferation.
In cancers involving B-cell malignancies, B-cell proliferation is rampant. BTK's role in B-cell maturation makes it an ideal target for therapeutics. When BTK is inhibited, the cell no longer initiates cellular pathways essential for survival and ultimately undergoes apoptosis.
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