Research in Review

Research in Review Focus on Lung Cancer

April 2022

J Clin Pathways. 2022;8(3):21-23.

Therapeutic Targeting of BAP1/ASXL3 Sub-Complex in SCLC

Investigators sought to discover the function of the oncogenic BAP1/ASXL3/BRD4 epigenetic axis in small-cell lung cancer (SCLC) by developing a next-generation BAP1 inhibitor, iBAP-II.

Afatinib Improves Survival in Patients with Advanced Lung Squamous Cell Carcinoma

When compared to chemotherapy, afatinib demonstrated superior PFS and comparable OS in immunotherapy-naive patients with advanced lung squamous cell carcinoma.

FDA Grants Fast Track Designation to Bemcentinib Combo in Advanced NSCLC

The FDA has granted Fast Track designation for a bemcentinib combo in patients with advanced NSCLC without actionable mutations.

Ensartinib vs Crizotinib for ALK-Positive NSCLC

Ensartinib demonstrated superior efficacy to crizotinib for patients with advanced ALK-positive NSCLC in a study published in JAMA Oncology.

Combining Chemo With Immunotherapy Does Not Improve OS in Patients with NSCLC

Adding chemotherapy to first-line durvalumab plus tremelimumab improved PFS, but not OS, compared to durvalumab plus tremelimumab alone in patients with NSCLC.

Dynamic Monitoring of CTCs Could Predict Prognosis in SCLC Patients

Dynamic monitoring of CTCs level may be an effective, non-invasive way to predict disease progression and prognosis in patients with SCLC.

Nivolumab Shows Potential Benefit for Patients with Malignant Mesothelioma

Nivolumab shows potential benefit for patients with relapsed malignant mesothelioma who progressed following platinum-based chemotherapy.

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The Value of Tissue-Based Genomic Profiling in Oncology

09/17/2024

Innovations in precision oncology have helped healthcare providers to create more personalized treatment plans and improve patient outcomes. View this special report to learn more.

Innovations in precision...

09/17/2024

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Shedding Light on Non-Small Cell Lung Cancer & Its Impact on Patients

04/03/2023

This supplement aims to raise awareness about non-small cell lung cancer (NSCLC) and its impact on patients by providing comprehensive information to help improve early detection and appropriate care.

This supplement aims to raise...

04/03/2023

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Brukinsa® (Zanubrutinib) for Chronic Lymphocytic Leukemia

03/31/2023

In this product monograph, read an interview with Jeff P. Sharman, MD, as he discusses important BRUKINSA® trial data including efficacy, safety, dosing, administration, and other relevant data. These key findings supported the Food and Drug...

In this product monograph, read...

03/31/2023

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Tumor Lysis Syndrome: Early Diagnosis and Management

01/04/2023

This review summarizes the diagnosis, pathophysiology, and evidence-based guidelines for the prevention and management of tumor lysis syndrome, a common, acute, life-threatening disease primarily in patients with hematologic cancers and solid...

This review summarizes the...

01/04/2023

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A Tumor Lysis Syndrome Risk Assessment and Its Impact on Patients

08/09/2022

In an interview with Journal of Clinical Pathways, Nicholas Short, MD, shares objectives on the design and benefits of MD Anderson’s Tumor Lysis Syndrome clinical assessment for patient risk and impact on patient care.

In an interview with Journal of...

08/09/2022

Journal of Clinical Pathways

Updated NCCN Guidelines on B-Cell Lymphomas

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Overview of the Updated NCCN Guidelines on B-Cell Lymphomas

06/15/2022

Robert Fee ;

Updated multiple times in 2022, the National Comprehensive Cancer Network (NCCN) Guidelines for B-Cell Lymphomas provide recommendations for the prevention, diagnosis, and management of malignancies.

Updated multiple times in 2022,...

06/15/2022

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Expanded Indication for Zanubrutinib: Marginal Zone Lymphoma and Waldenström’s Macroglobulinemia

06/10/2022

In an interview with Journal of Clinical Pathways, Mitul Gandhi, MD, reviews the clinical impact and treatment approaches and challenges for patients with marginal zone lymphoma and Waldenström’s macroglobulinemia.

In an interview with Journal of...

06/10/2022

Journal of Clinical Pathways

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Recommendations for Creating an Oncology Clinical Pathways Framework Tool Based on Payer, Provider, and Patient Priorities: Findings From the 2021 Care Pathways Working Group

05/20/2022

Robin T. Zon , MD, FACP, FASCO;

Gordon Kuntz ;

Winston Wong , PharmD;

The Journal of Clinical Pathways convened the 2021 Care Pathways Working Group to identify and reconcile the different pathway drivers for each stakeholder now and five years into the future, creating a framework tool based on oncology care...

The Journal of Clinical Pathways...

05/20/2022

Journal of Clinical Pathways

Overview of the Updated NCCN Guidelines on Triple-Negative Breast Cancer

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Overview of the Updated NCCN Guidelines on Triple-Negative Breast Cancer

12/15/2021

Deborah Abrams Kaplan ;

NCCN released updates to its practice guidelines on treating triple-negative breast cancer, featuring updates on sacituzumab govitecan recommendations and more.

NCCN released updates to its...

12/15/2021

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Navigating the Patient Journey for Unresectable Stage III Non-Small Cell Lung Cancer

09/16/2021

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09/16/2021

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11/12/2024

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Just 41% of oncology practice groups offer a general survivorship clinic for cancer survivors, according to a study published online in JNCI Cancer Spectrum.

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Evolving Oncology Pathways, CLL Treatment Advances, and the Role of Multidisciplinary Care Teams

11/12/2024

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Shaffee Bacchus, PharmD, discusses the evolution of oncology pathways, advancements in chronic lymphocytic leukemia (CLL) treatment, and the importance of multidisciplinary care teams in addressing comorbidities and enhancing patient quality...

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Journal of Clinical Pathways

Research in Review Focus on Lung Cancer

Therapeutic Targeting of BAP1/ASXL3 Sub-Complex in SCLC

Afatinib Improves Survival in Patients with Advanced Lung Squamous Cell Carcinoma

FDA Grants Fast Track Designation to Bemcentinib Combo in Advanced NSCLC

Ensartinib vs Crizotinib for ALK-Positive NSCLC

Combining Chemo With Immunotherapy Does Not Improve OS in Patients with NSCLC

Dynamic Monitoring of CTCs Could Predict Prognosis in SCLC Patients

Nivolumab Shows Potential Benefit for Patients with Malignant Mesothelioma

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