Spindle Cell Lipoma in the Posterior Neck

Haruka Tajima, MD; Toshihito Mitsui, MD, PhD; Hiromu Masuoka, MD, PhD; Masakatsu Hihara, MD, PhD; Atsuyuki Kuro, MD; Masashi Kihara, MD; Natsuko Kakudo, MD, PhD

Peer Reviewed

Interesting Cases

Spindle Cell Lipoma in the Posterior Neck

Haruka Tajima, MD; Toshihito Mitsui, MD, PhD; Hiromu Masuoka, MD, PhD; Masakatsu Hihara, MD, PhD; Atsuyuki Kuro, MD; Masashi Kihara, MD; Natsuko Kakudo, MD, PhD

Keywords

spindle cell lipoma

CD34

neck

March 2022

ISSN 1937-5719

Index ePlasty 2022;22:ic4

Case Description

A 71-year-old man presented with a slow-growing subcutaneous tumor (prevalent since 6 years of age) on the left posterior neck. The patient had no previous relevant medical history. On physical examination, a 4- × 3-cm tumor that was elastic, soft, and somewhat hypermobile (Figure 1A) was revealed. There was no pain, redness, or elevated temperature in or around the tumor site. Magnetic resonance imaging (MRI) showed a heterogeneous internal structure on T1-weighted and T2-weighted images (Figure 1B). No significant lymphadenopathy was found. During surgery, an incision was made directly on the tumor, and the tumor was removed along the excised skin in a spindle shape (Figure 2). Histopathological examination using hematoxylin-eosin staining showed mature adipocytes, spindle cell proliferation (Figure 3A), and CD34 positivity (Figure 3B). No nuclear pleomorphism or mitotic figure was observed. The patient was diagnosed with spindle cell lipoma (SCL). There has been no pain or tumor recurrence 4 months postsurgery.

Figure 1a — Figure 1. A) Preoperative findings. A 71-year-old man with an elastic, soft, somewhat immobile 4 × 3-cm tumor on the left posterior neck.

Figure 1b — Figure 1. B) Signal intensity of the tumor in left posterior neck on MRI scans. In this T2-weighted image, the tumor shows heterogeneous internal structures.

Figure 2. Operative findings, excised tumor.

Figure 3a — Figure 3. A) Histological findings of the excised tumor. Hematoxylin-eosin staining shows mature adipocytes and spindle cell proliferation.

Figure 3b — Figure 3. B)Histological findings of the excised tumor. Immunohistochemistry shows CD34 positivity.

Questions

How often does SCL occur?
What are the various useful approaches to diagnose SCL?
What are the characteristic pathological findings of SCL?
What is the differential diagnosis of SCL?

Q1. How often does SCL occur?

SCL is a subtype of lipoma, a benign tumor composed mainly of mature adipocytes and spindle-shaped cells.¹ SCL is rare and accounts for approximately 1.5% of all adipose tumors.² It is more common in males aged 40 to 70 years, with a predilection for the shoulder and posterior neck.^1,3

Q2. What are the various useful approaches to diagnose SCL?

MRI is useful in diagnosing SCL, which is characterized by a well-defined subcutaneous mass with high signal on T1- and T2-weighted images, low signal on fat-suppressed images, low-signal areas on T1- and T2-weighted images mixed with fatty components, and contrast effects only on nonfatty components.⁴

Q3. What are the characteristic pathological findings of SCL?

SCL is generally considered to be definitively diagnosed by histopathological examination. It is characterized by the proliferation of spindle-shaped cells, thick collagen bundles, mucous matrix in the interstitium, and scattered mast cells, which are composed of mature adipocytes.⁵ It is also characterized by CD34 positivity of spindle-shaped cells on immunohistochemical staining.^6,7

Q4. What is the differential diagnosis of SCL?

Differential diagnoses of SCL include fibrolipoma, pleomorphic lipoma, and liposarcoma. Fibrolipoma is characterized by collagenous fibrosis with few cellular components between fibrous tissues. Pleomorphic lipoma is a malignant tumor that affects the back of the head, shoulders, and back of men aged 40-70 years and has histopathological similarities to SCL; however, it is differentiated by atypical multinucleated giant cells called floret cells. Liposarcoma is a malignant tumor of the thigh, shoulder, and retroperitoneum in men aged 50–60 years. Histologically, liposarcoma differs from SCL in the presence of atypical spindle-shaped cells with pleomorphic nuclei and lipoblasts.⁸ Simple resection is sufficient for the treatment of SCL. There is no recurrence or metastasis and the prognosis is good.¹

Summary

We report the case of a 71-year-old man with SCL in the posterior neck. SCL is a relatively rare subtype of lipoma that predominantly affects the shoulder and posterior neck in men.

Acknowledgments

Affiliations: Department of Plastic and Reconstructive Surgery, Kansai Medical University, Osaka, Japan

Correspondence: Natsuko Kakudo, MD, PhD; kakudon@hirakata.kmu.ac.jp

Disclosures: The authors have no non-financial or commercial, proprietary, or financial interest in the products or companies described in the manuscript. The authors did not receive grants or a consultant honorarium to conduct the study, write the manuscript or otherwise assist in the development of the above-mentioned manuscript.

References

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