Repair of Facial Wound Utilizing Cryopreserved Human Umbilical Cord Allograft

Authors: Addison Yee, BS; Kyle P Davis, MD; Zachary Anderson, MD; Larry Hartzell, MD

Poster Number: CS-148

A poster presented at SAWC Fall describes the use of cryopreserved human umbilical cord allograft in a pediatric patient who suffered a dog bite to her left cheek and upper lip. Follow-up was performed at 1 week, 3 weeks, 4 months, and 1 year, when the patient underwent scar revision surgery, including wedge lip resection.

Human umbilical cord has demonstrated anti-inflammatory and anti-scarring properties due to the HC-HA/PTX complex located in the stroma of the amniotic membrane and umbilical cord, and it also contains epidermal growth factor, keratinocyte growth factor, and keratinocyte growth factor receptors that promote epithelialization. Craniofacial injuries are the most common type of trauma in the pediatric population, and human umbilical cord could be an attractive option that provides both wound closure and excellent reconstructive results.

References:

Fairbairn NG, Randolph MA, Redmond RW. The clinical applications of human amnion in plastic surgery. J Plast Reconstr Aesthet Surg. 2014;67(5 (sup2):):662-675.

Farhadihosseinabadi B, Farahani M, Tayebi T, et al. Amniotic membrane and its epithelial and mesenchymal stem cells as an appropriate source for skin tissue engineering and regenerative medicine. Artif Cells Nanomed Biotechnol. 2018;46431-440.

Braun TL, Xue AS, Maricevich RS. Differences in the Management of Pediatric Facial Trauma. Semin Plast Surg. 2017;31(2):118-122. doi:10.1055/s-0037-1601380

Poster reference:

Yee A, Davis KP, Anderson Z, Hartzell L. Repair of facial wound utilizing cryopreserved human umbilical cord allograft.