Key Apoptosis-Related Genes Identified in Psoriasis Pathogenesis

Key apoptosis-related genes and immune infiltration in the pathogenesis of psoriasis were identified in a recent study published in Hereditas.

Researchers aimed to explore the underlying functions of key apoptosis-related genes and the characteristics of immune filtration in psoriasis in a study that screened differentially expressed apoptosis-related genes (DEARGs) associated with psoriasis. The functions of DEARGs were also explored through a comprehensive bioinformatics analysis using GSE13355 and GSE3099. Tools used to analyze and gather genes included Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway, gene set enrichment analysis, protein–protein interaction network, and real-time quantitative polymerase chain reaction.

A total of 482 DEARGs were identified from GSE13355 and 32 from GSE30999. The DEARGs were commonly enriched in cell chemotaxis, receptor ligand activity, and signaling receptor activity. The viral protein interaction with cytokines and cytokine receptors was the maximally enriched pathway. A.770041, GNF.2, and WO2009093972 are possible targeted drugs for psoriasis. A total of 13 key DEARGs with upregulation were identified.

“Results of this study may reveal some insights into the underlying molecular mechanism of psoriasis and provide novel targeted drugs,” concluded the study authors.

Reference
Zou A, Kong Q, Sang H. Identification of key apoptosis-related genes and immune infiltration in the pathogenesis of psoriasis. Hereditas. Published online: June 22, 2022. doi:10.1186/s41065-022-00233-0