Intermediate Filament Cytoskeleton and PPAR Signaling Pathway Key Regulators of Psoriasis Lesions

According to a study published in Clinical, Cosmetic and Investigational Dermatology, the mRNA expression profile of psoriatic lesions was significantly different from nonlesion tissues and normal skin.

Researchers aimed to determine the factors present in psoriatic lesions by providing a comprehensive mRNA profile of patients with psoriasis and directions for further study of psoriasis molecular mechanisms. Transcriptome analysis was used to profile the mRNA expression of psoriatic lesions and nonlesion tissues from patients with psoriasis and healthy control individuals. The mRNA expression profiles were verified using quantitative real-time polymerase chain reaction.

A total of 237 differentially expressed genes were screened, identified, and determined to be enriched in the peroxisome proliferator-activated receptor (PPAR) signaling pathway and intermediate filament cytoskeleton. Gene expression of the following PPAR signaling pathway genes were significantly decreased in psoriatic lesions compared with healthy skin: ADIPOQ, AQP7, PLIN1, FABP4, and LPL. The intermediate filament cytoskeleton genes, including KRT27, KRT25, KRT71, KRT86, and KRT85, were also significantly decreased in psoriasis lesions.

“In summary, we screened psoriasis-related mRNA expression profiles by using bioinformatics approaches,” concluded the study authors. “The experimentally-validated [intermediate filament cytoskeleton and PPAR signaling pathway genes] are key regulators of psoriasis lesions,” they added.

Reference
Li X, Xing J, Wang F, et al. The mRNA expression profile of psoriatic lesion distinct from non-lesion. Clin Cosmet Investig Dermatol. Published online September 27, 2022. doi:10.2147/CCID.S385894