Changes In Systemic Immunity Among Patients With Psoriasis, Acne

According to a recent study published in Wiadomości Lekarskie, a link between changes in systemic immunity indexes and T cells amid an adequate humoral immunity has been established.

Researchers aimed to improve the diagnostics of common chronic dermatoses by studying the immune-pathogenetic features of psoriasis and acne in 114 patients with acne and 128 patients with psoriasis.

Changes in concentrations of stress-response mediators and decreased parameters of cellular immunity were detected in the blood serum of patients with psoriasis, regardless of disease duration. Patients with acne had varying degrees of changes in rates of systemic immunity with the most significant changes in depletion of T-cell immunity in patients with popular-pustular and pustular acne. Changes were more significant in patients with acne conglobate.

“In patients with acne and psoriasis, changes in systemic immunity indexes that indicate the formation of secondary immunodeficiency state T-cell link, amid an adequate humoral immunity have been found,” concluded the study authors.

Reference
Dashko M, Syzon O, Voznyak I, Chaplyk-Chyzho I. Study of immuno-pathogenetic features of psoriasis and acne’s course. Wiad Lek. 2022;75(suppl 2):422-426.