Pathogenesis Mechanism of Actinic Keratosis
UV radiation is the primary driver of actinic keratoses (AKs) and squamous cell carcinoma (SCC) development, triggering DNA damage, lipid oxidation, inflammation, and immunosuppression—ultimately leading to keratinocyte tumor growth. Dr Lain highlights the multifaceted impact of UV exposure and explores preventive strategies, including antioxidants to counteract lipid oxidation and sunscreen to mitigate multiple pathways of damage.
Ted Lain, MD, is a board-certified dermatologist and chief medical officer of Sanova Dermatology specializing in diagnosis and treatment of disorders of the hair, skin, and nails.
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