4 Trials From ACC.25: ALT-SHOCK2, FLAVOUR-II, PROTECT-TAVI, and FAME 3
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Join Morton Kern, MD1, Arnold Seto, MD, MPA2, and Bailey Estes, AGNP-C, MSN, RN-BC, RCIS, RNFA3, as they discuss four trials that were originally presented at the 2025 Scientific Session of the American College of Cardiology (ACC), held March 29-31, in Chicago, Illinois.
1Clinical Editor; Interventional Cardiologist, Long Beach VA Medical Center, Long Beach, California; Professor of Medicine, University of California, Irvine Medical Center; 2Director of Interventional Cardiology Research, University of California -Irvine School of Medicine; Section Chief, Cardiology, Long Beach VA Medical Center; 3Clinical Liaison and Development Specialist, Alleviant Medical
References
1. Morici N, Sacco A, Frea S, Rota M, Villanova L, Gravinese C, Dini CS, D'Ettore N, Maj G, D'Elio G, Potena L, Valente S, Sabatino M, Viola G, Garatti L, Tavecchia GA, Bertoldi L, Oliva F, Kapur NK, Tavazzi G, De Ferrari GM, Pappalardo F; Altshock-2 Investigators. Early Intra-Aortic Balloon Support for Heart Failure-Related Cardiogenic Shock: A Randomized Clinical Trial. J Am Coll Cardiol. 2025 Mar 21:S0735-1097(25)05334-3. doi: 10.1016/j.jacc.2025.03.003
2. Hu X, Zhang J, Yang S, Jiang J, Peng X, Lu D, Pan Y, Guo L, Li J, He W, Zhou H, Pu J, Huang J, Jiang F, Liu Q, Song D, Lu L, Cheng Z, Yang B, Ma J, Chen P, Li S, Meng Z, Tang L, Fan Y, Shin ES, Tu S, Nam CW, Fearon WF, Koo BK, Wang J; FLAVOUR II study group. Angiography-derived fractional flow reserve versus intravascular ultrasound to guide percutaneous coronary intervention in patients with coronary artery disease (FLAVOUR II): a multicentre, randomised, non-inferiority trial. Lancet. 2025 Mar 28:S0140-6736(25)00504-5. doi: 10.1016/S0140-6736(25)00504-5
3. Kharbanda RK, Kennedy J, Jamal Z, Dodd M, Evans R, Bal KK, Perkins AD, Blackman DJ, Hildick-Smith D, Banning AP, Baumbach A, Ludman P, Palmer S, Stables RH, Henderson R, Appleby C, Cotton J, Curzen N, Ozkor M, Byrne J, Aggarwal R, Das R, Doshi S, Watkins S, Muir DF, Anderson R, Chowdhary S, Varcoe R, Dorman S, Firoozi S, Chelliah R, Owens C, Redwood S, Prendergast B, Iqbal J, Ratib K, Dospinescu C, Suresh V, Cruden N, Rajathurai T, Malik IS, Wiper A, Costopoulos C, Khurana A, Banning A, Clayton T; BHF PROTECT-TAVI Investigators. Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation. N Engl J Med. 2025 Mar 30. doi: 10.1056/NEJMoa2415120
4. Fearon WF, Zimmermann FM, Ding VY, Takahashi K, Piroth Z, van Straten AHM, Szekely L, Davidavičius G, Kalinauskas G, Mansour S, Kharbanda R, Östlund-Papadogeorgos N, Aminian A, Oldroyd KG, Al-Attar N, Jagic N, Dambrink JE, Kala P, Angerås O, MacCarthy P, Wendler O, Casselman F, Witt N, Mavromatis K, Miner SES, Sarma J, Engstrøm T, Christiansen EH, Tonino PAL, Reardon MJ, Otsuki H, Kobayashi Y, Hlatky MA, Mahaffey KW, Desai M, Woo YJ, Yeung AC, Pijls NHJ, De Bruyne B. Outcomes after fractional flow reserve-guided percutaneous coronary intervention versus coronary artery bypass grafting (FAME 3): 5-year follow-up of a multicentre, open-label, randomised trial. Lancet. 2025 Mar 28:S0140-6736(25)00505-7. doi: 10.1016/S0140-6736(25)00505-7
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