New Inflammatory Markers May Help Monitor RA Disease Activity

Two novel inflammatory markers offer promise for assessing disease activity in patients with rheumatoid arthritis, according to a study in the journal Clinical Laboratory.

“The C-reactive protein to prealbumin ratio (CPR) and prealbumin to fibrinogen ratio (PFR) are two new inflammatory markers that were reported to have predictive value for the assessment of systemic inflammatory disease,” researchers explained.

In this retrospective study, researchers looked at links between CPR and PFR and the Disease Activity Score in 28 joints (DAS28) in 170 patients with rheumatoid arthritis compared with 120 healthy control subjects.

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Patients with rheumatoid arthritis, they found, had a significantly lower PFR and higher CPR compared with healthy controls.

CPR was positively correlated with C-reactive protein, erythrocyte sedimentation rate, and DAS-28 score in patients with rheumatoid arthritis, according to the study, while PFR was negatively correlated with C-reactive protein, erythrocyte sedimentation rate, and DAS-28 score in patients.

Both inflammatory markers had high area-under-the-curve levels, analysis showed.

—Jolynn Tumolo

Reference

Wang J, Xi H, Zhang K, et al. Circulating C-reactive protein to prealbumin ratio and prealbumin to fibrinogen ratio are two promising inflammatory markers associated with disease activity in rheumatoid arthritis. Clin Lab. 2020;66(5):10.7754/Clin.Lab.2019.190833. doi:10.7754/Clin.Lab.2019.190833