Life Threatening Sacral Wound in Alzheimer Patient Treated With Cationic Nanoparticle Dressing

Introduction: Chronic Pressure Ulcers, despite standard care, often are stalled in their healing due to unaddressed chronic biofilm. Resistant to antimicrobial agents, bacterial biofilms engender a chronic inflammatory response within the wound. Hence, anti-biofilm agents that specifically penetrate and kill biofilm pathogens can significantly reverse wound chronicity and lead to final healing. We present a 77-year-old end-stage Alzheimer patient with a life-threatening sacral abscess treated with a novel combination of cationic nanoparticles (NP)* and a tri-block polymer hydrogel**.Methods:After incision and drainage of abscess with debridement of underlying necrosis, the wound area was 432cm2 and 4cm deep. A compounded antimicrobial cream mixed with a NP cationic matrix* combined with a polymer hydrogel** was applied every day at home. After 4 weekly clinic debridement’s and noticeable improvement, treatment with only the hydrogel* was continued.Results:While initially approaching treatment as palliative care, the potentially life-threatening wound unexpectedly healed by 99% in approximately 12-weeks without the need for hospitalization. All dressings were performed by the family.Discussion: This case study mirrors many other successful wounds healed with this proprietary combination of an encapsulated NP cation matrix* with a thermoreversible polymer hydrogel **containing Octenidine. This new technology incorporates an abundance of cationic charges as well as heavy molecular weight poloxamers that directly disrupt the biofilm matrix.  Furthermore, they effectively kill associated pathogens, and prevent biofilm regrowth while fully augmenting wound repair.References:1. European Pressure Ulcer Advisory Panel, National Pressure Injury Advisory Panel and Pan Pacific Pressure Injury Alliance. Prevention and Treatment of Pressure Ulcers/Injuries: Clinical Practice Guideline. The International Guideline. Emily Haesler (Ed.). EPUAP/NPIAP/PPPIA: 2019. 2. Eleonora Russo * and Carla Villa. Poloxamer Hydrogels for Biomedical Applications. Pharmaceutics 2019, 11, 671; doi:10.3390/pharmaceutics11120671 3. Yu, R., Zhang, H., & Guo, B. (2021). Conductive biomaterials as bioactive wound dressing for wound healing and skin tissue engineering. Nano-microLetters, 14(1). https://doi.org/10.1007/s40820-021- 00751-y 4. Naskar, A., & Kim, K. (2020). Recent advances in Nanomaterial-Based Wound-Healing therapeutics. Pharmaceutics (Basel), 12(6), 499. https://doi.org/10.3390/pharmaceutics12060499