3rd Degree Burns in a Paraplegic Patient Treated with an Advanced Thermo-reversible Antiseptic Hydrogel

Introduction: Third degree burns represent a significant risk for infection and morbidity for affected patients. Hence, treatment is focused on preventing deep infection, limiting fluid loss, ameliorating pain, as well as promoting prompt tissue regeneration. We present a patient with third degree abdominal burns treated solely with a unique thermo-reversible antimicrobial polymer hydrogel* wound dressing until complete healing was achievedMethods:A 67-year-old paraplegic woman presented suffering from three week old 2nd and 3rd degree burns on the anterior abdomen induced inadvertently by a hair dryer resting at this location. While not acutely painful there was some regional discomfort. After evaluation and staging, the eschar was debrided from the wound margins. The patient was treated with a thermo-reversible polymer hydrogel *containing Octenidine applied directly to the burn areas under standard dressings. She subsequently changed her own dressings daily and returned weekly for follow up.Results:Substantial healing and reduction of discomfort was evident on the patient’s first return visit and the progress was sustained through the entire month she remained under care. Her wound completely healed within five weeks of treatment without becoming infected and with minimal scarring or contraction.           Discussion: This thermo-reversible high molecular weight polymer hydrogel* containing millions of micelles encapsulating the antimicrobial Octenidine effectively dissolves wound biofilm and associated pathogens while also facilitating tissue regeneration. This dramatic case mirrors the success obtained in many other chronic wounds treated with this unique antibiofilm and antimicrobial hydrogel. Further confirmational studies are pending.References:1. Eleonora Russo * and Carla Villa. Poloxamer Hydrogels for Biomedical Applications. Pharmaceutics 2019, 11, 671; doi:10.3390/pharmaceutics11120671 2. Yu, R., Zhang, H., & Guo, B. (2021). Conductive biomaterials as bioactive wound dressing for wound healing and skin tissue engineering. Nano-microLetters, 14(1). https://doi.org/10.1007/s40820-021-00751-y 3. Naskar, A., & Kim, K. (2020). Recent advances in Nanomaterial-Based Wound-Healing therapeutics. Pharmaceutics (Basel), 12(6), 499. https://doi.org/10.3390/pharmaceutics12060499