A Case Series for Management of Complicated Diabetic Foot Wounds

Introduction: It is well documented that diabetic foot ulcers are a complication that impacts healthcare systems and patient quality of life. Even more problematic are patients with significant co-morbidities and a history of complications. Traditional Standard of Care (SOC) treatments are inadequate for many of these patients, necessitating advanced wound care products like human placental membranes. These products are intended as covering for acute and chronic wounds. We present here a series of four complicated patients with difficult-to-heal diabetic foot ulcers. Human placental membrane which was retention-processed (RE-AC) had a profound effect on these patients.Methods:Case 1 involved a diabetic patient with previous 5 th partial ray amputation presenting with macerated, undermined ulcers of the foot. Case 2 is a diabetic hemodialysis patient who received kidney and pancreas transplants. The patient has osteomyelitis of the foot, gout and limited vascularity at a full-thickness ulcer of the toe. Case 3 involves a diabetic patient with multiple amputations who developed necrosis on the right foot down to bone. RE-AC (AW2) was applied to these wounds every 7 days.Results:The application of RE-AC proved to be very effective in the treatment of these patients. The patients demonstrated clinical improvement with within one to three applications of the skin substitute. Two patients went on to complete closure. Discussion: Even in the most challenging cases, the use of this RE-AC, as a wound covering, offers significant improvement in the timeline to closure, which reduces the risk for limb threatening infection, and allowing the patient to return to a more normal lifestyle. This translates to reduced treatment costs, and optimized resource utilization in a healthcare setting. Diabetic foot ulcers, DFU, placental membrane, retrospective, amnion chorion, ACReferences: