Advancing Therapeutic Solutions for Burn Wounds: Potential Use of Noninvasive Ultrasound-Driven Splenic Stimulation

Introduction: Burn injuries globally impact millions yearly, causing morbidity, mortality, and tissue loss. Socioeconomic disparities and outdated therapeutic treatments stress the need for innovative and accessible medical approaches. This review explores the potential of noninvasive splenic stimulation, particularly with pulsed focused ultrasound (pFUS), as a solution for burn wound care.Methods:A systematic review revealed a gap in the literature, identifying sparse articles on splenic stimulation and a singular ongoing clinical trial related to ultrasound therapy. Epidemiological data have highlighted global burn injury trends and socioeconomic factors influencing incidence and severity. The pathophysiology section outlined the wound healing stages, emphasizing the impact of burn injury severity on outcomes using Jackson's burn wound model.Results: Currently available therapies, such as biologics, cultured tissue products, placental-based grafts, growth factor and moist wound therapy, are not without limitations. The review introduces non-invasive ultrasound-driven splenic stimulation targeting the cholinergic anti-inflammatory pathway (CAP). Findings from animal studies indicate accelerated wound healing in diabetic conditions. Ongoing clinical trials are currently exploring the potential effectiveness of focused pulsed ultrasound on the spleen for burn wounds.Discussion: Noninvasive splenic stimulation, specifically with pFUS, presents a new medical therapeutic avenue for burn wound care, showing accelerated healing and improved cytokine markers. Ongoing clinical trials signal potential for cost-effective, widespread treatments. Urgently needed in socioeconomically challenged regions, transformative therapies promise enhanced accessibility and outcomes for patients and physicians.References: