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Poster
1584448
Association between Anhedonia Severity and Clinical and Humanistic Outcomes Among US Adults with Major Depressive Disorder
Psych Congress 2023
This work was sponsored by Janssen Scientific Affairs, LLC
Objective: Anhedonia is a key symptom and part of the diagnostic criterion of major depressive disorder (MDD). However, the relationship between anhedonia severity and the clinical and humanistic burden among patients with MDD is poorly understood.
Methods: Adults diagnosed with depression were identified from the 2022 US National Health and Wellness Survey (NHWS). These participants with depression were recontacted to participate in an online cross-sectional survey to collect data on anhedonia, using the Snaith-Hamilton Pleasure Scale (SHAPS). Multivariable analyses assessed the association of SHAPS score with health-related outcomes, while controlling for age, sex, race, comorbidity burden, and insurance status. The SHAPS (score range: 14 to 56) assesses the ability to experience pleasure, with higher scores indicating greater levels of anhedonia.
Results: Of the 8,270 NHWS respondents with depression who met inclusion criteria, 665 completed the recontact survey (mean age=58.4, 78.3% female). Mean SHAPS score was 25.4 (range: 14 to 47); higher SHAPS was associated with greater depression severity (r=0.24, p
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