Biofilm

Case Series

Effect of a New Purified Collagen Matrix With Polyhexamethylene Biguanide on Recalcitrant Wounds of Various Etiologies: A Case Series

02/28/2018

Dimitrios Lintzeris

Karen Vernon

Heather Percise

Andy Strickland

Kari Yarrow

Amber White

Mary Gurganus

Susan Sherrod

Kathleen Vergin

Laura Johnson

In order to control biofilm formation, sequester proteolytic enzymes, and provide a biocompatible scaffold to support healing, the investigators utilize a purified collagen matrix containing polyhexamethylene biguanide (PCMP) in a case series...

In order to control biofilm...

02/28/2018

Wounds

Original Research

Clinic-based Debridement of Chronic Ulcers Has Minimal Impact on Bacteria

02/28/2018

Paul J. Kim

Christopher E. Attinger

Thomas Bigham

Robert Hagerty

Samantha Platt

Ersilia Anghel

John S. Steinberg

Karen K. Evans

The aim of this study is to evaluate the change in bacterial amounts with sharp debridement in a clinical setting. Bacterial autofluorescence, quantitative cultures, semiquantitative cultures, and qualitative speciation were performed...

The aim of this study is to...

02/28/2018

Wounds

Original Research

Clinical Assessment of a Biofilm-disrupting Agent for the Management of Chronic Wounds Compared With Standard of Care: A Therapeutic Approach

01/26/2018

Daniel Kim

William Namen II

January Moore

Mauricia Buchanan

Valerie Hayes

Matthew F. Myntti

Albert Hakaim

The authors study the use of a biofilm-disrupting wound gel designed for wound management to determine if disrupting chronic wound biofilm would be therapeutically efficacious.

The authors study the use of a...

01/26/2018

Wounds

Original Research

Preliminary Results of a Topically Applied Bacteria-specific Antibiotic Gel to Improve Wound Healing

09/25/2017

Caitlin S. Zarick

Elizabeth A. Benkert

Noah G. Oliver

John S. Steinberg

Karen K. Evans

Christopher E. Attinger

Zinnia M. Rocha

Paul J. Kim

This is a retrospective chart review evaluating the authors’ early experience with the use of bacteria-specific antimicrobial gel therapy on chronic lower extremity wounds that have not responded to standard therapy.

This is a retrospective chart...

09/25/2017

Wounds

Original Research

The Effect of Negative Pressure Wound Therapy With Antiseptic Instillation on Biofilm Formation in a Porcine Model of Infected Spinal Instrumentation

06/07/2017

Devinder P. Singh

Arvind U. Gowda

Karan Chopra

Michael Tholen

Sarah Chang

Vasilios Mavrophilipos

Nina Semsarzadeh

Yvonne Rasko

Luther Holton III

This study evaluates the effect of negative pressure wound therapy with antiseptic instillation (NPWTi) in the clearance of infection and biofilm formation in an in vivo model of infected spinal implants compared to traditional treatment...

This study evaluates the effect...

06/07/2017

Wounds

Original Research

Effect of Negative Pressure Wound Therapy With Instillation on Bioburden in Chronically Infected Wounds

05/30/2017

Chun Yang

Selena G. Goss

Sean Alcantara

Greg Schultz

John C. Lantis II

The goal of this study was to evaluate the effectiveness of NPWT with instillation (NPWTi) on biofilm of chronic wounds. A prospective, randomized trial was conducted. Following sharp debridement, 20 patients with chronic wounds were...

The goal of this study was to...

05/30/2017

Wounds

Original Research

New Surfactant-based Dressing Product to Improve Wound Closure Rates of Nonhealing Wounds: A European Multicenter Study Including 1036 Patients

07/06/2016

Francesco Paolo Palumbo

Keith G. Harding

Franca Abbritti

Sarah Bradbury

Jürgen Dietmar Cech

Nicola Ivins

Dieter Klein

Gabrielle Menzinger

Frans Meuleneire

Simone Seratoni

Christoph Zölß

Dieter Mayer

A new surfactant-based biomaterial containing the antimicrobial 1% silver sulfadiazine (SSD) was developed at the University of Virginia (Charlottesville, VA) to improve outcomes for nonhealing wounds. This study’s objective was to clinically...

A new surfactant-based...

07/06/2016

Wounds

Original Research

Femoral Vein Cannulation in the Treatment of Osteomyelitis

06/08/2016

Alan Coulson

Angela Peek

Dianne Haugen

06/08/2016

Wounds

Original Research

A New Acid-oxidizing Solution: Assessment of Its Role on Methicillin-resistant Staphylococcus aureus (MRSA) Biofilm Morphological Changes

10/15/2015

Noemi D’Atanasio

Alessandra Capezzone de Joannon

Giorgina Mangano

Marisa Meloni

Nadia Giarratana

Claudio Milanese

Serena Tongiani

Biofilms represent a key challenge in the treatment of chronic wounds, as they are among the main reasons for delays in chronic wound healing. This in vitro study was aimed at evaluating the activity of a new acid-oxidizing solution (AOS) on...

Biofilms represent a key...

10/15/2015

Wounds

Original Research

Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency

12/09/2014

Serhan Sakarya

Necati Gunay

Meltem Karakulak

Barcin Ozturk

Bulent Ertugrul

The aim of this study was to investigate the effect of stabilized hypochlorous acid solution (HOCl) on killing rate, biofilm formation, antimicrobial activity within biofilm against frequently isolated microorganisms and migration rate of...

The aim of this study was to...

12/09/2014

Wounds