Giovanni Luigi De Maria, MD1,2; Francesco Burzotta, MD, PhD2; Carlo Trani, MD2; George Kassimis, MD, MSc, PhD1; Giancarlo Pirozzolo, MD2; Niket Patel, MBBS, BSc, MRCP1; Ilaria Dato, MD2; Italo Porto, MD, PhD2; Antonio Maria Leone, MD, PhD2; Giampaolo Niccoli, MD, PhD2; Rajeh Kharbanda, PhD, MRCP1; Filippo Crea, MD2; Adrian P. Banning, MBBS, MD, FRCP1