comparative effectiveness

Research in Review

Intensified Regimens More Effective Than Standard Therapy in DLBCL

06/28/2017

JCP Editors

Intensified regimens improve event-free survival (EFS) and overall survival (OS) in patients newly diagnosed with diffuse large B-cell lymphoma (DLBCL) compared with standard therapy, according to research presented...

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06/28/2017

Journal of Clinical Pathways

Research in Review

Insulin Pump Therapy Inferior to Insulin Injections in Cost-Effectiveness

06/23/2017

JCP Editors

Continuous subcutaneous insulin infusion (CSII) is associated with increased hypoglycemia encounters and health care expenditures, according to research published in the American Journal of Managed Care (June 21,...

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06/23/2017

Journal of Clinical Pathways

Research in Review

High-Dose Chemo Yields Similar Survival Outcomes in Patients With AML

06/22/2017

JCP Editors

Standard induction chemotherapy is noninferior to high-dose chemotherapy in patients with newly diagnosed acute myeloid leukemia (AML), according to new research published in the Journal of Clinical Oncology...

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06/22/2017

Journal of Clinical Pathways

Research in Review

Comparative Effectiveness Study Examines Treatment Options for Type of Colorectal Cancer

06/22/2017

JCP Editors

A recent study compared the effects of first-line chemotherapy with two different drugs in patients with advanced or metastatic colorectal cancer, published in JAMA (2017;317[23]:2392-2401). ----- Related...

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06/22/2017

Journal of Clinical Pathways

Research in Review

Higher Dose Does Not Improve Efficacy of Gastric Cancer Treatment

06/20/2017

JCP Editors

A higher dose treatment for a type of metastatic gastric adenocarcinoma showed equivalent efficacy and safety, according to research published in the Journal of Clinical Oncology (published online June 2017;...

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06/20/2017

Journal of Clinical Pathways

Research in Review

TKI Safe and Effective in Pediatric CML

06/15/2017

JCP Editors

A recent study demonstrated high response rates and tolerable safety profiles in pediatric patients with chronic myeloid leukemia (CML) after treatment with a tyrosine kinase inhibitor (TKI). ----- Related...

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06/15/2017

Journal of Clinical Pathways

Research in Review

Recent Breast Cancer HER2 Testing Guideline Update Produces Similar Positivity Rate

06/14/2017

JCP Editors

Updates to the 2013 human epidermal growth factor receptor 2 (HER2) testing guideline in breast cancer did not affect the overall positivity rate or the proportion of patients eligible for targeted therapy, according...

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06/14/2017

Journal of Clinical Pathways

Research in Review

Analyzing DLBCL Circulating Tumor DNA Helps Predict Treatment Response

05/31/2017

JCP Editors

Noninvasive sampling of diffuse large B-cell lymphoma (DLBCL) circulating tumor DNA enables early detection of focal and broad somatic copy number alterations, according to research that will be presented at the 2017...

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05/31/2017

Journal of Clinical Pathways

Research in Review

Trastuzumab Emtansine Improves OS in Patients With HER2+ Breast Cancer

05/19/2017

JCP Editors

Patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer benefit from an estimated 7 additional months of survival if treated with trastuzumab emtansine rather than the physician’s choice...

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05/19/2017

Journal of Clinical Pathways

Research in Review

Targeted Therapy Improves Disease-Free Survival in Intermediate-Risk NSCLC

05/18/2017

JCP Editors

Adjuvant treatment with the targeted therapy gefitinib (Iressa, AstraZeneca) significantly improved disease-free survival (DFS) over standard of care after surgery for patients with non–small cell lung cancer...

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05/18/2017

Journal of Clinical Pathways