Morton J. Kern, MD, with contributions from Steve Bailey, MD, University of Texas Health Science Center at San Antonio, Texas; Steve Balter, PhD, Columbia University, New York, New York; Charles Chambers, MD, Hershey, Pennsylvania; Prashant Kaul, MD, University of North Carolina, Chapel Hill, North Carolina; Ajay Kirtane, MD, SM, Columbia University, New York, New York; Mike Ragosta, MD, University of Virginia, Charlottesville, Virginia; Gurpreet Sandhu, MD, PhD, Mayo Clinic, Rochester, Minnesota.