Abstracts

Quality of life in late-stage cancer patients on immune checkpoint inhibitor therapy

Background Immune checkpoint inhibitors are a successful therapy for cancer patients and patient related outcomes compared with cytotoxics. Unfortunately Immune checkpoi...

06/27/2022

DNA damage repair (DDR) germline mutations (GMs) in pancreatic ductal adenocarcinoma (PDAC): A mono-institutional retrospective study

Background GMs in DDR genes, in particular BRCA1/2, are associated with increased cancer risk, among which PDAC. Their identification is crucial, not only for clinical r...

06/27/2022

Diabetes promotes the progression of pancreatic ductal adenocarcinoma via the interaction between transforming acinar cells and cancer cells through AKT/CEBPβ/LCN2 pathway

Background Pancreatic cancer, in which pancreatic ductal adenocarcinoma (PDAC) is the most common type, ranks the seventh most leading cause of cancer death in both sexe...

06/27/2022

A multicenter phase II study of mFOLFOX6 in advanced gastric cancer patients with severe peritoneal metastases: WJOG10517G

Background Advanced gastric cancer (AGC) patients with severe peritoneal metastases, defined as massive ascites and/or inadequate oral intake, have been excluded from pi...

06/27/2022

CXCL8 is a valid potential prognostical marker for esophageal squamous cell carcinoma

Background Esophageal cancer is one of the most malignant cancers worldwide. Deciphering of the complexity of the tumor and tumor microenvironment by single-cell sequenc...

06/27/2022

Conditional relative survival in non-metastatic esophagogastric cancer between 2006 and 2019: A population-based study

Background Overall survival estimates are informative at primary diagnosis but become less relevant over time. Conditional survival is an accurate method to estimate the...

06/27/2022

Quality of life (QoL)-based end-points for patients with advanced pancreatic ductal adenocarcinoma (aPDAC): Results from the PanDA prospective observational study

Background Adequate design of clinical trials using QoL-based primary-end points to assess benefit derived from supportive interventions such as exercise, nutrition or c...

06/27/2022

The impact of the multidisciplinary team (MDT) in the management of colorectal cancer (CRC)

Background The management of CRC is complex, particularly in metastatic disease, where it is crucial the definition of disease burden, the assessment of radiological res...

06/27/2022

Can a patient navigator increase quality of life in colorectal cancer patients? The WeGuide trial

Background An estimated one-third of patients with cancer will experience clinically significant distress, manifesting as anxiety or depression that is associated with t...

06/27/2022

Pre-surgical staging and surveillance after curative treatment for pancreatic ductal adenocarcinoma (PDAC): Survey of practice in the United Kingdom (UK)

Background Differences in pre-operative staging and surveillance after curative treatment for PDAC hamper interpretation of outcome data. Methods ...

06/27/2022