Abstracts

Study of the hedgehog signaling pathway in colorectal cancer: Association with wild type RAS status

Background EGFR antibodies are efficient in the treatment of patients with RAS wild type metastatic colorectal cancer (mCRC). However, 25% of those patients resist to th...

06/27/2022

Study of the composition of the inflammatory infiltrate in patients with colorectum cancer

Background Colorectal cancer is a real public health problem, it ranks third among cancers in terms of frequency the world and second in terms of mortality. Several envi...

06/27/2022

Real-world evidence of anlotinib in patients with advanced hepatocellular carcinoma and clinical role of α-fetoprotein

Background Anlotinib, a novel multi-targeting tyrosine kinase inhibitor (TKI), has been investigated in a variety of malignant tumors and has shown efficacy in clinical ...

Y. Yin ;

B. Yin ;

X. Bi ;

06/27/2022

Can immune checkpoint inhibitors plus surgery cure advanced mismatch repair-deficient cancer?

Background There is a strong body of evidence supporting use of immune checkpoint inhibitors (ICI) in unresectable mismatch repair-deficient (MMRd) / microsatellite unst...

Ioanna Panagiotopoulou ;

Elizabeth Smyth ;

Harriet Baker ;

Hugo Ford ;

Robert O'Neill ;

06/27/2022

Importance of tumor sampling in transcriptomics-based risk stratification

Background The variability of gene expression signatures across tumor sites has been previously documented [Stewart et al. 2017]. However, how this information can be ex...

06/27/2022

Updated results of Maria Sklodowska-Curie National Research Institute of Oncology gastric cancer cohort: Indirect comparison between adjuvant chemoradiation and perioperative chemotherapy in gastric cancer patients

Background Gastric cancer is associated with poor prognosis. Curative resection alone leads to a dismal outcome of gastric and GEJ adenocarcinoma. In the western gastric...

06/27/2022

Impact of death-associated protein-3 (DAP3) and DAP3 binding cell death enhancer 1 (DELE1) on drug sensitivity in colorectal cancer cells

Background Death association protein-3 (DAP3) is an important growth/death regulator of cells, has been found to have important clinical value in various cancer. DELE1 (...

06/27/2022

Frequency of RAS variants in Bulgarian patients with metastatic colorectal cancer

Background One common genetic factor affecting the colorectal cancer (CRC) development and the outcome is the mutational status of the RAS gene family. Somatic variants ...

06/27/2022

Performance characteristics of a tumor-informed circulating tumor DNA (ctDNA) minimal residual disease (MRD) assay in stage 1-3 colorectal cancer (CRC) in clinical practice

Background Detection of MRD has emerged as a tool for risk stratification in patients with early stage CRC with potential implication for adjuvant therapy. Recently, the...

06/27/2022

Estrogen receptors influence the epithelial-to-mesenchymal transition of pancreatic cancer cell lines

Background Pancreatic ductal adenocarcinoma (PDAC) represents the majority of diagnosed pancreatic cancers and its mortality rates are well above 90%. This bleak scenari...

06/27/2022