biofilm

Literature Review

Bromelain-Based Enzymatic Debridement: Mechanism of Action in the Wound Environment. A Literature Review

01/02/2025

This review focuses on the mechanism of action and clinical function of bromelain-based enzymatic debridement (BBD) in the context of wound care, focusing on the mechanism of action of BBD and its formulation for chronic wounds in particular.

This review focuses on the...

01/02/2025

Wounds

Original Research

An Open-Label, Proof-of-Concept Study Assessing the Effects of Bromelain-Based Enzymatic Debridement on Biofilm and Microbial Loads in Patients With Venous Leg Ulcers and Diabetic Foot Ulcers

12/20/2023

Robert J. Snyder , MD, PhD, DPM, FACFAS, CWS-P, MBA;

Adam J. Singer ;

Cyaandi R. Dove , DPM;

Yaron Shoham ;

Edward Grant ;

Garth A. James ;

Aya Ben Yaakov ;

Stephen Heisler ;

Elinor deLancey Pulcini ;

Lior Rosenberg ;

Howard Petusevsky ;

This study examines the efficacy of a bromelain-based debridement agent for reduction of biofilm in patients with chronic wounds, including diabetic foot ulcers and venous leg ulcers.

This study examines the efficacy...

12/20/2023

Wounds

Original Research

Clinicomicrobiological Profile of Podiatric Infections: A Prospective, Cross-sectional Study

07/12/2023

Shalini Shenoy Mulki ;

Sevitha Bhat ;

Archana Bhat K. , MD, MBBS;

Swathi Holla VR ;

Researchers screened specimens from 117 patients to assess clinicomicrobiological profile of podiatric infections and identify prevalent biolfim producers.

Researchers screened specimens...

07/12/2023

Wounds

Case Report

Salvage of Infected Orthopedic Hardware With Intraoperative and Postoperative Hypochlorous Acid Instillations

01/09/2023

Eric Clayman , MS;

Zackery Beauchamp , BS ;

Jared Troy , MD;

This article presents 2 patients with orthopedic hardware infection. In both patients, hypochlorous acid was used intraoperatively during debridement to soak the hardware for 5 minutes.

This article presents 2 patients...

01/09/2023

ePlasty

Original Research

The Effect of a Biofilm-disrupting Wound Gel vs. a Broad-spectrum Antimicrobial Ointment on a Chronic Wound Microbiome: A Secondary Analysis Associating Clinical and Laboratory Findings

12/21/2022

Matthew F. Myntti ;

Patricia Stevenson , MSN, ACNS-BC, CWS;

Dianne Porral ;

Valerie Y. Hayes ;

This original research study examines a previous study to decipher whether laboratory data shows a correlation between treatment using a novel biofilm-disrupting wound gel and various endpoints, concluding that a reduction in bioburden may...

This original research study...

12/21/2022

Wounds

Videos

Promising Results of Bromelain-based Enzymatic Debridement

10/06/2022

Robert J. Snyder , MD, PhD, DPM, FACFAS, CWS-P, MBA;

In this research presentation, Dr. Robert J. Snyder reports on the results of an open phase 2 study assessing the safety, efficacy, and pharmacologic effects of bromelain-based enzymatic debridement product on biofilm and microbial loads in...

In this research presentation,...

10/06/2022

Wounds

Videos

Next Steps in Studying Bromelain-based Enzymatic Debridement on Biofilm and Microbial Loads

10/06/2022

Robert J. Snyder , MD, PhD, DPM, FACFAS, CWS-P, MBA;

In this interview, Dr. Robert J. Snyder provides insight into future plans to further the results of an open phase 2 study assessing the safety, efficacy, and pharmacologic effects of bromelain-based enzymatic debridement product on biofilm...

In this interview, Dr. Robert J....

10/06/2022

Wounds

Guest Editorial

Biofilm-Based Wound Management: Implications for Clinical Practice

09/02/2022

Laura Swoboda , DNP, APNP, FNP-C, FNP-BC, CWOCN-AP, WOCNF;

Dr Laura Swoboda discusses the clinical applications for biofilm management

Dr Laura Swoboda discusses the...

09/02/2022

Wound Management & Prevention

News

Review Identifies Advancements, Gaps in Treating Wound Biofilms

07/06/2022

Carol Brzozowski ;

Because of the high financial cost of biofilm treatment and the high burden on patient outcomes, researchers reviewed existing methods for biofilm detection and eradication.

Because of the high financial...

07/06/2022

Wound Care

Case Series

Efficacy of Hydromechanical Therapy in Nonhealing, Chronic Wounds as a Cost- and Clinically Effective Wound Care Modality

11/02/2021

Patrick V. Marasco Jr., MD, FACS;

Lifei Guo , MD, PhD;

Sydney Char , MD;

Haley DesJardins ;

Yung-Chang Hsu ;

In this case series, the authors aimed to demonstrate that hydromechanical therapy with pressurized irrigation can be a cost-effective and clinically effective wound care modality.

In this case series, the authors...

11/02/2021

Wounds