biofilm

Clinical Effectiveness of a Biofilm Disrupting Surgical Lavage in Reducing Bacterial Plate Counts in Total Knee Arthroplasty Revision Surgery in Known Cases of Prosthetic Joint Infection

Introduction: Bacteria can cycle between two distinct modes of growth, as free-floating “planktonic” and attached “biofilm.” Opportunistically seizing hold of acute and chronic wounds onc...

10/25/2019

Effect of a Ph Lowering Wound Therapeutic on MMP Levels and Bacterial Biofilm Colonization of Chronic Nonhealing Wounds

Introduction: Patients with chronic lower extremity wounds are reported to have inflammation associated with biofilm bacterial colonization of the wound bed. A novel therapy, Theraworx (T...

10/25/2019

Two Phase 1 Clinical Studies Evaluating the Cumulative Irritation and Contact Sensitization on Intact and Abraded Skin of MBN-101, a Novel Antimicrobial Product in Development for Diabetic Foot Ulcer Infection

Background: MBN-101, a novel product in a new class of antimicrobial compounds with unique, broad-spectrum activity against bacteria and biofilm, is in clinical development for the t...

08/12/2019

Combined Sequential Effect of a Purified Collagen Matrix with Polyhexamethylene Biguanide, Followed by a Complete Placental Allograft, on a Diverse Group of Chronic Wounds of Various Etiologies: A Case Series

Introduction: Chronic wounds frequently stall in the inflammatory phase, and are characterized by elevated pro-inflammatory molecules and proteases. The presence of biofilm is suspec...

08/12/2019

Effectiveness of Pyruvate Dehydrogenase Enzyme (PDH) in the Dispersion of Established Biofilms of Pseudomonas Aeruginosa (ATCC 27312) Using a Deep Partial Thickness Porcine Wound Model

Background: Pseudomonas aeruginosa (PA) is a gram-negative microorganism with a high capability of forming biofilm. New technologies have been developed to either prevent biofilm fro...

07/29/2019

Preliminary Evaluation of a Purified Native Collagen Matrix with Polyhexamethylene Biguanide Reducing Methicillin Resistant Staphylococcus aureus Infections and Altering Cytokine Profile Using a Porcine Deep Dermal Wound Model

Background: There are a variety of wound matrices designed to treat both acute and chronic wounds, and enhance the healing process. However, patients suffering from these wounds often enc...

02/09/2019

Video

3 Debridement Questions for the Wound Clinic: Video Series

02/08/2019

Daniel Kapp, MD

In this exclusive three-part video series, Today’s Wound Clinic (TWC) speaks with Daniel Kapp, MD, chief of plastic surgery at Palm Beach Gardens (FL) Medical Center and medical director of the Wound Healing & Hyperbaric Center at Jupiter...

In this exclusive three-part...

02/08/2019

Today's Wound Clinic