DFU

A Prospective, Randomized, Multi-Center Comparative Study of Amniotic Membrane Wound Graft Application versus Tissue Engineered Skin Substitute in the Management of Non Healing Diabetic Foot Ulcers

Background: Allogeneic grafts derived from amnion/chorion are known to be efficacious in healing chronic diabetic foot ulcerations (DFUs).  Aseptically processed grafts may have...

08/13/2019

Time to Recurrence of Plantar Foot Ulceration in Patients Undergoing Percutaneous Tendo-Achilles Lengthening

Background: Equinus contracture is a common affliction in patients with diabetic foot ulceration. Percutaneous tendo-Achilles lengthening (TAL) is a useful method to alleviate peak planta...

08/12/2019

Treatment of Hard-to-Heal Diabetic Foot Ulcers with a Novel Decellularized Hepatic-Derived Wound Matrix: Outcomes from a Prospective Multicenter Trial

Background: One million diabetics in the US will develop diabetic foot ulcers (DFUs); 150,000 ulcers will become chronic. 5-24% of these patients will require amputation. Patients wh...

07/29/2019

Use of Remote Ischemic Conditioning on the Treatment of Diabetic Wounds

Introduction: Remote Ischemic Conditioning (RIC) activates the body's natural protective physiology against reperfusion injury and the tissue damage caused by low oxygen levels. More...

07/29/2019

A Multi-Center, Multi-National, Prospective, Randomized, Double-Blinded, Placebo Controlled Trial Comparing Adjunctive Cycling Topical Wound Oxygen Therapy to Gold Standard Wound Care in the Treatment of Diabetic Foot Ulcers

Aim: Non-healing DFUs lead to increased mortality and morbidity.(a) Our rigorous multinational RCT protocol was designed to explore the efficacy of a unique Cyclical Pressurized Topical O...

07/15/2019

Nutrition

Diabetic Foot Ulcers and Nutrition: Making the Connection

07/03/2019

Nancy Collins, PhD, RDN, LD, NWCC, FAND

Nutrition often is not the first thing clinicians think about when treating patients with a diabetic foot ulcer (DFU), but it is a critical component of the wound healing process. Nutrition is connected to every facet of healing, including...

Nutrition often is not the first...

07/03/2019

Today's Wound Clinic

A Multicenter, Randomized, Single-Blind Trial Comparing the Efficacy of Viable Cryopreserved Placental Membrane to Human Fibroblast-Derived Dermal Substitute for the Treatment of Chronic Diabetic Foot Ulcers

Purpose: Randomized controlled clinical trials (RCTs), the gold standard to determine treatment efficacy against control, have demonstrated advantages of skin substitutes for the treatmen...

06/10/2019

Does USWR Quality Reporting Make it Easier to Do the Right Thing?

Objective: We have previously shown a large gap in practice for diabetic foot ulcer (DFU) off-loading and venous leg ulcer (VLU) compression. We wished to determine the impact of quality ...

03/12/2019

Open-Label Extension Phase Of The Chronic Diabetic Foot Ulcer Multicenter, Controlled, Randomized Clinical Trial Confirms Benefits Of Viable Cryopreserved Placental Membrane For Wound Closure And Reduction Of Adverse Events

Study Objective: In a multicenter, blinded, randomized, controlled clinical trial (RCT), viable cryopreserved placental membrane (vCPM)* applications to chronic DFUs resulted in high...

01/09/2019