Measures of the Patient-Reported Outcomes Measurement Information System (PROMIS) can be useful in assessing psoriatic arthritis (PsA) disease activity from the patient’s perspective, according to new study findings presented at the 2019 American College of Rheumatology (ACR)/Association of Rheumatology Professionals (ARP) Annual Meeting.

A combination of patient-reported outcomes (PROs), objective measures of disease activity, and clinical assessment help guide treatment decisions. However, disparities between PROs and clinical measures of disease activity can lead to overtreatment or undertreatment of patients, as well as patient dissatisfaction.

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To address this, Juliette Yedimenko, MD, from the Cleveland Clinic, and colleagues conducted a cross-sectional study within the Psoriatic Arthritis Research Consortium (PARC), a cohort of adults with PsA who met the Classification Criteria for Psoriatic Arthritis (CASPAR).

The researchers assessed the connection between minimal disease activity (MDA) and PROs as measured by the National Institutes of Health PROMIS Global Health questionnaire, as well as evaluated the effect of demographics, PsA-related comorbidities, and the number of comorbidities on PROMIS Global Health and MDA status.

A total of 235 participants—129 of whom were in MDA and 106 of whom were not—were included in the analysis.

The researchers determined that patients in MDA had significantly higher PROMIS physical function and mental function T-scores, as well as improved fatigue T-scores compared with patients not in MDA.

While a positive correlation was observed between MDA scores and PROMIS scores in physical and mental function domains, the correlation was strongest for PROMIS physical function T-score. The researchers also found a moderate correlation between MDA and PROMIS fatigue T-score.

Univariate analysis showed a statistically significant association between hypertension and the number of comorbidities with MDA status. A statistically significant association was not observed in multivariate analysis.

The researchers noted that although MDA was associated with a positive effect on patients’ physical function, mental function, and fatigue domains, the patients with a greater number of comorbidities were less likely to be in MDA.

“In this study, the PROMIS Physical domain had a higher correlation with MDA scores compared to the Mental domain and PROMIS Fatigue,” the researchers concluded. “PROMIS measures may be a useful tool in assessing disease activity from the patient’s perspective.”

—Colleen Murphy

Reference:

Yedimenko J, Jin Y, Ogdie A, et al. Are PROMIS measures associated with minimal disease activity in psoriatic arthritis? [abstract 838]. Arthritis Rheumatol. 2019;71(suppl 10). Presented at: 2019 ACR/ARP Annual Meeting; November 8-13, 2019; Atlanta, GA. https://acrabstracts.org/abstract/are-promis-measures-associated-with-minimal-disease-activity-in-psoriatic-arthritis/. Accessed November 6, 2019.