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Research Confirms Importance of Exercise, NSAIDs in Hip and Knee OA
In a recent review, researchers discussed the importance of understanding hip and knee osteoarthritis (OA), the positive impact of weight loss and exercise in managing the disease, and how the additional use of a topical or oral nonsteroidal anti-inflammatory drugs (NSAIDs), for applicable patients, can complement treatment.
“Hip and knee OA is among the most prevalent and disabling joint diseases, affecting an estimated more than 240 million people worldwide, including an estimated more than 32 million in the US. Osteoarthritis is the most frequent reason for activity limitation in adults,” the authors reported.
Patients with OA with immobilizing pain and movement limitations experience greater comorbidities, and are often more sedentary than individuals without OA. Reduced activity can lead to higher disease-related risks and discomfort.
“The cornerstones of OA management include exercises, weight loss if appropriate, and education—complemented by topical or oral nonsteroidal anti-inflammatory drugs (NSAIDs) in those without contraindications. Intra-articular steroid injections provide short-term pain relief and duloxetine has demonstrated efficacy. Opiates should be avoided,” the authors concluded.
“Clinical trials have shown promising results for compounds that arrest structural progression. Persons with advanced symptoms and structural damage are candidates for total joint replacement. Racial and ethnic disparities persist in the use and outcomes of joint replacement, the investigators added.”
—Angelique Platas
Reference
Katz JN, Arant KR, Loeser RF. Diagnosis and treatment of hip and knee osteoarthritis: a review. JAMA. 2021;325(6):568–578.
