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Clinical Pearls

Navigating the Cost, Challenges, and Complexities of Ketamine for Depression Treatment

Andrew Penn, MS, PMHNP, explores ketamine as a rapidly acting antidepressant, unraveling its effectiveness and limitations. Penn discusses the evolving questions around redosing, financial implications, and pragmatic considerations for clinicians in managing patients with these treatments.

For more depression clinical pearls, rapid refreshers, and perspectives, visit the Depression and MDD Learning Library.


Andrew Penn, MS, PMHNP, has practiced as a psychiatric/mental health nurse practitioner, treating veterans and training residents at the San Francisco Veterans Administration Hospital. As a researcher, he collaborates on psychedelics studies of psilocybin and MDMA in the Translational Psychedelics Research (TrPR) lab at UCSF, serving as Co-PI on a phase 2 study of psilocybin for depression and is currently working on a study using psilocybin to treat depression in patients with Parkinson's disease. He is a cofounder of the Organization of Psychedelic and Entheogenic Nurses, he has published on psychedelics in the American Journal of Nursing, Frontiers in Psychiatry, and The Journal of Humanistic Psychotherapy. Penn has also lectured at SXSW, Aspen Health Ideas Festival, the Singapore Ministry of Health, TEDx, and Oxford University.


Transcript coming soon.