Skip to main content

Major Depressive Disorder News

older woman with depression
News
04/16/2025
Maria Mantas
A recent systematic review found weak quality evidence to support the effectiveness of several commonly prescribed pharmacological and non-pharmacological interventions for treatment-resistant depression (TRD) in older adults. 
A recent systematic review found weak quality evidence to support the effectiveness of several commonly prescribed pharmacological and non-pharmacological interventions for treatment-resistant depression (TRD) in older adults. 
A recent systematic review found...
04/16/2025
Psych Congress Network
A woman taking a pill
News
04/09/2025
Maria Mantas
Quetiapine may be more clinically effective than lithium as an augmentation option for reducing symptoms of treatment-resistant depression (TRD), a type of major depressive disorder (MDD), according to a recent study.
Quetiapine may be more clinically effective than lithium as an augmentation option for reducing symptoms of treatment-resistant depression (TRD), a type of major depressive disorder (MDD), according to a recent study.
Quetiapine may be more...
04/09/2025
Psych Congress Network
Study on MDD - stock image
News
03/24/2025
Jolynn Tumolo
Plans have been announced for a phase II clinical study of investigational lithium therapy AL001 for MDD, focusing on its unique properties and its effect on lithium delivery in the brain compared with marketed lithium salts.
Plans have been announced for a phase II clinical study of investigational lithium therapy AL001 for MDD, focusing on its unique properties and its effect on lithium delivery in the brain compared with marketed lithium salts.
Plans have been announced for a...
03/24/2025
Psych Congress Network
Pill bottle
News
02/18/2025
Jolynn Tumolo
An ongoing phase 2b trial investigating adjunctive ALTO-300 in patients with MDD and inadequate antidepressant response will add 50 participants after results from a planned interim analysis showed favorable findings, Alto Neuroscience...
An ongoing phase 2b trial investigating adjunctive ALTO-300 in patients with MDD and inadequate antidepressant response will add 50 participants after results from a planned interim analysis showed favorable findings, Alto Neuroscience...
An ongoing phase 2b trial...
02/18/2025
Psych Congress Network
Major Depressive Disorder MDD
News
01/03/2025
Jolynn Tumolo
Common in patients with unipolar depression, hypomanic symptoms are associated with both treatment-resistant depression and reduced remission of suicidal thoughts, according to a study in the Journal of Affective Disorders.
Common in patients with unipolar depression, hypomanic symptoms are associated with both treatment-resistant depression and reduced remission of suicidal thoughts, according to a study in the Journal of Affective Disorders.
Common in patients with unipolar...
01/03/2025
Psych Congress Network
depression stock photo
News
12/05/2024
Jolynn Tumolo
A trio of newly identified mitophagy-related genes in astrocytes are promising biomarkers for diagnosing and treating MDD, according to a study in the Journal of Affective Disorders.
A trio of newly identified mitophagy-related genes in astrocytes are promising biomarkers for diagnosing and treating MDD, according to a study in the Journal of Affective Disorders.
A trio of newly identified...
12/05/2024
Psych Congress Network
Depression
News
11/22/2024
Meagan Thistle
A study presented in a poster at Psych Congress 2024 in Boston, Massachusetts, aimed to understand the characteristics and treatment patterns of patients with MDD who experience prominent anhedonia compared to those who do not or who have low...
A study presented in a poster at Psych Congress 2024 in Boston, Massachusetts, aimed to understand the characteristics and treatment patterns of patients with MDD who experience prominent anhedonia compared to those who do not or who have low...
A study presented in a poster at...
11/22/2024
Psych Congress Network
Patient survey
News
11/06/2024
Jolynn Tumolo
Key barriers to tardive dyskinesia (TD) diagnosis include a lack of communication with the health care professional, lack of a physical exam, and low educational and socioeconomic status, according to a survey of adults with TD symptoms.
Key barriers to tardive dyskinesia (TD) diagnosis include a lack of communication with the health care professional, lack of a physical exam, and low educational and socioeconomic status, according to a survey of adults with TD symptoms.
Key barriers to tardive...
11/06/2024
Psych Congress Network
depression stock photo
News
11/04/2024
Jolynn Tumolo
Adjunctive treatment with the atypical antipsychotic lumateperone improved depressive symptoms and severity more than adjunctive placebo in patients with MDD with inadequate response to previous antidepressant therapy, according to a poster...
Adjunctive treatment with the atypical antipsychotic lumateperone improved depressive symptoms and severity more than adjunctive placebo in patients with MDD with inadequate response to previous antidepressant therapy, according to a poster...
Adjunctive treatment with the...
11/04/2024
Psych Congress Network
Psilocybin
News
10/08/2024
Meagan Thistle
While intensive treatments with psilocybin and the serotonin reuptake inhibitor (SSRI) escitalopram were associated with long-term improvements in major depressive disorder (MDD) symptom severity, recent phase 2 double-blind, randomized,...
While intensive treatments with psilocybin and the serotonin reuptake inhibitor (SSRI) escitalopram were associated with long-term improvements in major depressive disorder (MDD) symptom severity, recent phase 2 double-blind, randomized,...
While intensive treatments with...
10/08/2024
Psych Congress Network