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Ketamine Reduces Suicidal Ideation in Treatment-Resistant Patients
Ketamine could be an effective treatment for suicidal ideation (SI) and suicide risk in patients with treatment-resistant depression (TRD), according to a study published in the Journal of Affective Disorders.
“Ketamine significantly reduced SI and depression across the sample,” lead author Jessica R. Gilbert, MD, National Institute of Mental Health, and co-authors noted.
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The study consisted of 29 drug-free participants with TRD, including 12 who had previously attempted suicide. Patients were experiencing a major depressive episode that lasted at least 4 weeks, were unresponsive to at least 1 medication during the episode, and scored 20 or higher on the Montgomery-Asberg Depression Rating Scale (MADRS).
Researchers collected magnetoencephalographic (MEG) data by having patients perform an attentional dot probe task with emotional face stimuli at baseline and then again several hours after ketamine infusion. Synthetic aperture magnetometry was used to project source power in the theta, alpha, beta, and gamma frequencies for angry-neutral, happy-neutral, and neutral facial expressions during a one-second period.
“Post-ketamine, attempters had improved accuracy and non-attempters had reduced accuracy on the task,” the authors found.
Ketamine reduced levels of SI and depression and resulted in improved task accuracy in previous attempers. Non-attempters had reduced accuracy on the task post-ketamine. SI was positively associated with gamma power in regions of the frontal and parietal cortices across groups. Ketamine reduced the association between alpha power and SI for angry faces in the brain region responsible for regulating sensory attentiveness.
“The findings highlight key differences in band-limited power between attempters and non-attempters and reinforce previous findings that ketamine has distinct response properties in patients with a suicide history,” researchers concluded.
