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Good, moderate, and poor functioning of adult patients with schizophrenia treated with aripiprazole once-monthly or paliperidone palmitate once-monthly in the Qualify study
Introduction QUALIFY was a 28-week, randomized, open-label, rater-blinded, head-to-head study (NCT01795547) evaluating effectiveness of aripiprazole once-monthly (AOM 400) vs paliperidone...
10/08/2020
Onset and Resolution of Key Adverse Events in Valbenazine-Treated Patients with Tardive Dyskinesia: Pooled Post Hoc Analyses from Two Long-Term Clinical Trials
Background: Tardive dyskinesia (TD) is a persistent and potentially disabling movement disorder associated with prolonged exposure to antipsychotics and other dopamine receptor blocking a...
10/08/2020
Functioning in de novo and rollover patients with bipolar I disorder receiving aripiprazole once-monthly in a 52-week, open-label study
Objectives: Aripiprazole once-monthly 400 mg (AOM 400) is a long-acting injectable formulation of aripiprazole licensed in the US, Canada and Australia for maintenance treatment of adults...
10/08/2020
Non-Healthcare Societal Burden of Schizophrenia Among Veterans
Introduction: Schizophrenia (SCZ) is a severe mental disorder imposing substantial healthcare burden to society. Data quantifying the non-healthcare societal burden of SCZ is limited, esp...
10/08/2020
Measuring Antidepressant Primary Adherence Among Insured Patients With Major Depressive Disorder Using Linked Electronic Health Record and Administrative Claims Data
Major depressive disorder (MDD) is challenging to treat. Antidepressants are prescribed to manage symptoms; the first step toward effective treatment is for patients to fill their new pre...
10/08/2020
Medication Adherence, Healthcare Resource Utilization, and Costs Among Medicaid Beneficiaries With Schizophrenia Treated With Once-monthly Paliperidone Palmitate or Once-every-three-months Paliperidone Palmitate
Background: Antipsychotics with reduced dosing frequency may improve adherence and clinical outcomes for patients with schizophrenia. This study compared adherence, persistence, healthcar...
10/08/2020
Impact of Lemborexant on Patient-Reported Insomnia-Related Worry/Distress and Interference With Daily Functioning Over 6 Months: Results From SUNRISE-2
 INTRODUCTION: The insomnia severity index (ISI) is a self-report instrument that evaluates perception of insomnia severity. In Study 303 (SUNRISE-2), lemborexant (LEM) showed greater red...
10/08/2020
Long-term Efficacy of Lurasidone in Pediatric Bipolar Depression: Post-hoc Analysis of Response, Remission and Recovery
Background: The aim of this analysis was to evaluate the long-term efficacy of lurasidone in achieving response and remission in children and adolescents with bipolar depression.
10/08/2020
Investigating Patient Characteristics as Predictors of Engagement Response to Adjunctive Brexpiprazole in Major Depressive Disorder
Background: Treatment with adjunctive brexpiprazole in major depressive disorder (MDD) has been shown to improve 'patient engagement', a concept related to one’s energy, interest, and o...
10/08/2020
Patient-Reported Effects of Adjunctive Brexpiprazole on Calming and Engagement in Major Depressive Disorder: Post Hoc Analysis of Clinical Trial Exit Interviews
Background: Calming patients (without sedation) and increasing engagement (without overactivation) are important components of the successful treatment of major depressive disorder (MDD)....
10/08/2020

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