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Pimavanserin, a selective serotonin inverse agonist/antagonist at the 5-HT2A/C receptors, is being actively studied for multiple indications. The CLARITY clinical trial program is evaluat...
10/27/2020
Up to 70% of individuals with schizophrenia experience inadequate response to antipsychotic treatment potentially due to insufficient exposure due to nonadherence or to medication ineffec...
10/27/2020
Introduction: Previous studies have documented increased risk of motor vehicle accidents (MVAs) in patients with obstructive sleep apnea (OSA); however, clinical practices for diagnosing/...
10/25/2020
Objective: A pooled analysis evaluated reductions in migraine and headache days among chronic migraine (CM) patients with comorbid depression (scores ≥10 on the 9-item Patient Health Ques...
10/25/2020
Background: Treatment-resistant depression (TRD) is a relatively common occurrence in clinical practice, with up to 50% to 60% of patients not achieving adequate response following antide...
10/21/2020
BACKGROUND: Comorbidities complicate clinicians' efforts to manage major depressive disorder (MDD). Pre-existing conditions and drug-drug interactions (DDI) may limit the array of safe ph...
10/19/2020
Background: The benefits of telehealth from a social, financial, and practical sense are well established. However, there are many gaps in the literature regarding telemedicine services i...
10/19/2020
Background: There are no established treatment guidelines for tardive dyskinesia (TD) based on movement severity. The 12-week ARM-TD and AIM-TD studies in TD patients with baseline Abnorm...
10/18/2020
Background: Vesicular monoamine transporter 2 (VMAT2) inhibitors including valbenazine are first-line therapies for tardive dyskinesia (TD), a persistent movement disorder associated with...
10/18/2020
In 2 placebo-controlled studies of adults with attention-deficit/hyperactivity disorder (ADHD), SHP465 mixed amphetamine salts (MAS) extended-release significantly reduced ADHD-Rating Sca...
10/08/2020

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