News

Maintenance Pazopanib Does Not Yield OS Improvement in Advanced Ovarian Cancer

12/03/2019

Although pazopanib extended PFS in certain patients with advanced ovarian cancer, the drug was not tied to improved median OS.

Although pazopanib extended PFS...

12/03/2019

Oncology

News

Nivolumab Plus Bevacizumab Active in Patients With Relapsed Ovarian Cancer

12/02/2019

Nivolumab plus bevacizumab led to response rates of 40.0% and 16.7% in patients with platinum-sensitive and platinum-resistant epithelial ovarian cancer.

Nivolumab plus bevacizumab led...

12/02/2019

Oncology

News

Tamoxifen Therapy Plus Ovarian Suppression Improves DFS in HR-Positive Breast Cancer

11/07/2019

Findings from a phase 3 study show that adding 2 years of ovarian suppression to tamoxifen therapy for patients with HR-positive breast cancer increased survival rates.

Findings from a phase 3 study...

11/07/2019

Oncology

News

Low KIF7 Expression Predicts Poor Prognosis in Epithelial Ovarian Cancer

11/04/2019

Study findings posit KIF7 as a useful independent prognostic predictor in patients with epithelial ovarian cancer.

Study findings posit KIF7 as a...

11/04/2019

Oncology

News

Higher Antral Follicle Count With Hemostatic Sealant After Ovarian Endometrioma Surgery

10/11/2019

Hemostatic sealant after laparoscopic cystectomy of ovarian endometriomas led to a greater increase in 3-month antral follicle count postsurgery compared with bipolar coagulation in a recent study.

Hemostatic sealant after...

10/11/2019

Oncology

News

Veliparib Added to Front-Line Chemotherapy Improves PFS in Ovarian Cancer

09/30/2019

Veliparib added induction chemotherapy, followed by veliparib maintenance significantly prolongs PFS over chemotherapy alone in women with high-grade serous ovarian carcinoma.

Veliparib added induction...

09/30/2019

Oncology

News

Niraparib Associated With Longer PFS in Newly Diagnosed Ovarian Cancer

09/30/2019

Niraparib is associated with significantly longer PFS than placebo in newly diagnosed advanced ovarian cancer, according to results from the phase 3 PRIMA study.

Niraparib is associated with...

09/30/2019

Oncology

Recent News

News

Intraoperative Radiation Therapy May Improve Survival For Certain Patients With Recurrent Cervical or Endometrial Cancer

11/14/2024

Allison Casey ;

According to a retrospective study, there was an appreciable survival gain for well-selected patients with recurrent or persistent endometrial or cervical cancer who receive intraoperative radiation therapy.

According to a retrospective...

11/14/2024

Oncology

News

Amrubicin Plus Irinotecan Demonstrates Promising Efficacy, Safety for Chemotherapy-Naïve Patients With Extensive-Disease Small Cell Lung Cancer

11/14/2024

Stephanie Holland ;

According to results from the phase 2 LC 08-01 trial, amrubicin plus irinotecan demonstrated promising efficacy and safety among chemotherapy-naïve patients with extensive-disease small cell lung cancer.

According to results from the...

11/14/2024

Oncology

News

Addition of Bempegaldesleukin to Nivolumab Does Not Benefit Cisplatin-Ineligible Patients With First-Line Advanced Urothelial Carcinoma

11/13/2024

Stephanie Holland ;

Results from the phase 2 PIVOT-10 trial demonstrated that the addition of bempegaldesleukin to first-line nivolumab did not improve outcomes for cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma.

Results from the phase 2...

11/13/2024

Oncology

News

Mirdametinib for Adult and Pediatric Patients With Neurofibromatosis Type 1 With Plexiform Neurofibromas

11/12/2024

Allison Casey ;

According to a phase 2b trial, mirdametinib demonstrated significant confirmed objective response rates with deep and durable reductions of volume of target plexiform neurofibromas and clinically meaningful improvements to health-related...

According to a phase 2b trial,...

11/12/2024

Oncology

News

Epirubicin Plus Cyclophosphamide and Docetaxel Reduces Long-Term Risk of Recurrence for Patients With TOP2A Normal Early Breast Cancer

11/12/2024

Stephanie Holland ;

According to final results from the DBCG 07-READ trial, the addition of epirubicin to cyclophosphamide and docetaxel reduced long-term risk of breast cancer recurrence among patients with TOP2A normal early breast cancer.

According to final results from...

11/12/2024

Oncology

News

Pembrolizumab Plus Chemotherapy For Patients With High-Risk Endometrial Cancer

11/11/2024

Allison Casey ;

According to results from a phase 3 trial, pembrolizumab plus chemotherapy did not improve DFS among patients with high-risk endometrial cancer. However, there may be a benefit among patients with mismatch report-deficient disease.

According to results from a...

11/11/2024

Oncology

FDA Approval

FDA Grants Approval to Obecabtagene Autoleucel for R/R B-Cell Precursor Acute Lymphoblastic Leukemia

11/08/2024

On November 8, 2024, the FDA approved CD19-directed genetically modified autologous T cell immunotherapy obecabtagene autoleucel for the treatment of patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.

On November 8, 2024, the FDA...

11/08/2024

Oncology

News

Naporafenib in Combination With Rineterkib or Tremetinib for KRAS- or BRAF-Mutant Non-Small Cell Lung Cancer

11/07/2024

Allison Casey ;

While naporafenib plus rineterkib and naporafenib plus trametinib both had acceptable safety profiles, antitumor activity was limited among patients with KRAS-/BRAF-mutant non-small cell lung cancer.

While naporafenib plus...

11/07/2024

Oncology

News

Addition of Concurrent Thoracic Radiotherapy to First-Line TKI Therapy Improves Survival for Patients With EGFR-Mutated Non-Small Cell Lung Cancer

11/06/2024

Stephanie Holland ;

According to results from a phase 3 trial, the addition of concurrent thoracic radiotherapy to first-line icotinib improved survival among patients with EGFR-mutated oligo-organ metastatic non-small cell lung cancer.

According to results from a...

11/06/2024

Oncology

News

Ipilimumab After PD-1 Inhibition Failure Among Patients With Metastatic Melanoma

11/05/2024

Allison Casey ;

A single-center real-world study found the use of ipilimumab in the second-line was an effective therapy for patients with metastatic BRAF/NRAS-wildtype metastatic melanoma without brain metastases.

A single-center real-world study...

11/05/2024

Oncology