News

Exposure to Radiation Earlier in Life Increases Leukemia Risk

08/03/2018

Exposure to ionizing radiation at cumulative doses <100 mSV in childhood or adolescence significantly increases a person’s risk for acute myeloid leukemia and acute lymphoblastic leukemia.

Exposure to ionizing radiation...

08/03/2018

Oncology

News

High Rates of Complete Remission in B-Cell Malignancies With CAR T-Cells Cultured Using Faster Technique

06/26/2018

Treatment of patients with relapsed/refractory B-cell malignancies by CAR T-cells cultured using a new technique achieved high complete remission rates.

Treatment of patients with...

06/26/2018

Oncology

News

New Regimens Improve Survival in Patients With T-Cell Cancers

06/07/2018

New regimens show the highest survival rates to date for two types of T-cell malignancies.

New regimens show the highest...

06/07/2018

Oncology

News

Correlation of CD19 Expression With Responses and Relapse After CAR-T Therapy

05/24/2018

Chimeric antigen receptor T-cell therapy is effective in a certain group of patients with B-cell acute lymphoblastic leukemia.

Chimeric antigen receptor T-cell...

05/24/2018

Oncology

News

Biomarker Predicts Response to CAR-T Therapy for Patients With CLL

05/10/2018

Researchers may have found the reason some patients with advanced CLL do not respond to chimeric antigen receptor T-cell therapy.

Researchers may have found the...

05/10/2018

Oncology

News

FDA Grants Expanded Approval for Treatment of ALL

03/29/2018

The FDA has granted expanded approval to a treatment for adults and children with ALL.

The FDA has granted expanded...

03/29/2018

Oncology

News

Durable Remission in Pediatric, Young Adult Patients With R/R B-Cell ALL After CAR-T Therapy

02/09/2018

A global study showed durable remission with long-term persistence in pediatric and young adults with relapsed or refractory B-cell ALL after a single infusion of a CAR T-cell therapy.

A global study showed durable...

02/09/2018

Oncology

News

Long-Term Benefits of CD19 CAR-T Therapy in ALL

02/02/2018

Results of a long-term follow-up study show that CAR-T therapy in adults with acute lymphoblastic leukemia may produce durable responses.

Results of a long-term follow-up...

02/02/2018

Oncology

Recent News

News

Intraoperative Radiation Therapy May Improve Survival For Certain Patients With Recurrent Cervical or Endometrial Cancer

11/14/2024

Allison Casey ;

According to a retrospective study, there was an appreciable survival gain for well-selected patients with recurrent or persistent endometrial or cervical cancer who receive intraoperative radiation therapy.

According to a retrospective...

11/14/2024

Oncology

News

Amrubicin Plus Irinotecan Demonstrates Promising Efficacy, Safety for Chemotherapy-Naïve Patients With Extensive-Disease Small Cell Lung Cancer

11/14/2024

Stephanie Holland ;

According to results from the phase 2 LC 08-01 trial, amrubicin plus irinotecan demonstrated promising efficacy and safety among chemotherapy-naïve patients with extensive-disease small cell lung cancer.

According to results from the...

11/14/2024

Oncology

News

Addition of Bempegaldesleukin to Nivolumab Does Not Benefit Cisplatin-Ineligible Patients With First-Line Advanced Urothelial Carcinoma

11/13/2024

Stephanie Holland ;

Results from the phase 2 PIVOT-10 trial demonstrated that the addition of bempegaldesleukin to first-line nivolumab did not improve outcomes for cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma.

Results from the phase 2...

11/13/2024

Oncology

News

Mirdametinib for Adult and Pediatric Patients With Neurofibromatosis Type 1 With Plexiform Neurofibromas

11/12/2024

Allison Casey ;

According to a phase 2b trial, mirdametinib demonstrated significant confirmed objective response rates with deep and durable reductions of volume of target plexiform neurofibromas and clinically meaningful improvements to health-related...

According to a phase 2b trial,...

11/12/2024

Oncology

News

Epirubicin Plus Cyclophosphamide and Docetaxel Reduces Long-Term Risk of Recurrence for Patients With TOP2A Normal Early Breast Cancer

11/12/2024

Stephanie Holland ;

According to final results from the DBCG 07-READ trial, the addition of epirubicin to cyclophosphamide and docetaxel reduced long-term risk of breast cancer recurrence among patients with TOP2A normal early breast cancer.

According to final results from...

11/12/2024

Oncology

News

Pembrolizumab Plus Chemotherapy For Patients With High-Risk Endometrial Cancer

11/11/2024

Allison Casey ;

According to results from a phase 3 trial, pembrolizumab plus chemotherapy did not improve DFS among patients with high-risk endometrial cancer. However, there may be a benefit among patients with mismatch report-deficient disease.

According to results from a...

11/11/2024

Oncology

FDA Approval

FDA Grants Approval to Obecabtagene Autoleucel for R/R B-Cell Precursor Acute Lymphoblastic Leukemia

11/08/2024

On November 8, 2024, the FDA approved CD19-directed genetically modified autologous T cell immunotherapy obecabtagene autoleucel for the treatment of patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.

On November 8, 2024, the FDA...

11/08/2024

Oncology

News

Naporafenib in Combination With Rineterkib or Tremetinib for KRAS- or BRAF-Mutant Non-Small Cell Lung Cancer

11/07/2024

Allison Casey ;

While naporafenib plus rineterkib and naporafenib plus trametinib both had acceptable safety profiles, antitumor activity was limited among patients with KRAS-/BRAF-mutant non-small cell lung cancer.

While naporafenib plus...

11/07/2024

Oncology

News

Addition of Concurrent Thoracic Radiotherapy to First-Line TKI Therapy Improves Survival for Patients With EGFR-Mutated Non-Small Cell Lung Cancer

11/06/2024

Stephanie Holland ;

According to results from a phase 3 trial, the addition of concurrent thoracic radiotherapy to first-line icotinib improved survival among patients with EGFR-mutated oligo-organ metastatic non-small cell lung cancer.

According to results from a...

11/06/2024

Oncology

News

Ipilimumab After PD-1 Inhibition Failure Among Patients With Metastatic Melanoma

11/05/2024

Allison Casey ;

A single-center real-world study found the use of ipilimumab in the second-line was an effective therapy for patients with metastatic BRAF/NRAS-wildtype metastatic melanoma without brain metastases.

A single-center real-world study...

11/05/2024

Oncology