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Low KIF7 Expression Predicts Poor Prognosis in Epithelial Ovarian Cancer
Study findings posit KIF7 as a useful independent prognostic predictor in patients with epithelial ovarian cancer (Lancet Oncol. 2019 Oct 24. Epub ahead of print).
Yaoshan Yao, MD, Department of Obstetrics and Gynecology, Third Affiliated Hospital, Southern Medical University, Guangzhou, China, conducted a study of 113 paraffin-embedded tumor tissues from patients with epithelial ovarian cancer to evaluate KIF7 expression and its prognostic value in this setting. Tissues were assessed for KIF7 expression via immunohistochemistry.
In addition, Dr Yao et al collected 22 fresh epithelial ovarian cancer tissues and their matched paratumor tissues from the Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, between August 2013 and March 2019. These samples were subjected to reverse-transcription quantitative PCR analysis to detect the mRNA expression of KIF7.
Findings showed that KIF7 expression was lower in cancer versus paratumor tissues and tied to recurrence-free survival and overall survival in patients with epithelial ovarian cancer.
Furthermore, in multivariate logistic regression analysis, low KIF7 expression was shown to be an independent predictor of poor survival.
“In conclusion, KIF7 has a tumor suppressor role in epithelial ovarian cancer and is a useful independent prognostic predictor. It may hold important value for the clinical diagnosis and treatment of epithelial ovarian cancer,” Dr Yao and colleagues reported.—Hina Porcelli
