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Positive Safety Outcomes When Switching Between Biosimilars and Reference Biologics
10/30/2023
"This first systematic review using statistical methods to address the risk of switching patients between reference biologics and biosimilars finds no difference in the safety profiles or immunogenicity rates in patients who were switched and...
"This first systematic review using statistical methods to address the risk of switching patients between reference biologics and biosimilars finds no difference in the safety profiles or immunogenicity rates in patients who were switched and...
"This first systematic review...
10/30/2023
First Report Managed Care
News
E-Cigarette Use Associated With Asthma Among US Adolescents
10/30/2023
This article investigates the factors associated with e-cigarette use among US adolescents and explores the relationship between e-cigarette use and asthma. Researchers provide insights into public health strategies to reduce e-cigarette use...
This article investigates the factors associated with e-cigarette use among US adolescents and explores the relationship between e-cigarette use and asthma. Researchers provide insights into public health strategies to reduce e-cigarette use...
This article investigates the...
10/30/2023
First Report Managed Care
News
Changing Trends in Hemophilia Treatment
10/27/2023
“With other novel therapies (including gene therapy) entering the US market, it is important to document the variability in existing prescribing practices among broad-based cohorts of clinicians,” explain study authors.
“With other novel therapies (including gene therapy) entering the US market, it is important to document the variability in existing prescribing practices among broad-based cohorts of clinicians,” explain study authors.
“With other novel therapies...
10/27/2023
First Report Managed Care
News
Comparative Assessment of Immunogenicity Profiles: A Crucial Factor in Biosimilar Development
10/27/2023
“Additional information on titers and subgroup analysis may be warranted to elucidate the critical attributes of immunogenicity impact and to aid in forming cost-effective strategies for biosimilar development,” said researchers.
“Additional information on titers and subgroup analysis may be warranted to elucidate the critical attributes of immunogenicity impact and to aid in forming cost-effective strategies for biosimilar development,” said researchers.
“Additional information on...
10/27/2023
First Report Managed Care
News
The Impact of International Price Referencing on Innovation and Access to Cell and Gene Therapies
10/26/2023
“Studies suggest that IRP may lead to price decreases in the short term. However, applying these methods carelessly, without a comprehensive assessment of how IRP might impact long-term innovation, could negatively impact all stakeholders,”...
“Studies suggest that IRP may lead to price decreases in the short term. However, applying these methods carelessly, without a comprehensive assessment of how IRP might impact long-term innovation, could negatively impact all stakeholders,”...
“Studies suggest that IRP may...
10/26/2023
First Report Managed Care
News

Evaluating Treatments for Demodex Blepharitis 
10/26/2023
A systematic review and meta-analysis reveals the efficacy of various treatments for Demodex blepharitis, showing that local treatments may be more promising due to lower systemic side effects.
A systematic review and meta-analysis reveals the efficacy of various treatments for Demodex blepharitis, showing that local treatments may be more promising due to lower systemic side effects.
A systematic review and...
10/26/2023
First Report Managed Care
News
Aflibercept May Improve Anatomic Progression in Nonproliferative Diabetic Retinopathy, But Not Visual Acuity
10/26/2023
“Aflibercept as a preventive strategy, as used in this trial, may not be generally warranted for patients with NPDR without CI-DME,” said researchers.
“Aflibercept as a preventive strategy, as used in this trial, may not be generally warranted for patients with NPDR without CI-DME,” said researchers.
“Aflibercept as a preventive...
10/26/2023
First Report Managed Care
News
Early Detection Tool for Psoriatic Arthritis in Psoriasis Patients
10/24/2023
The model demonstrates good performance, which can be adjusted based on its intended use, such as screening or targeting high-risk individuals for intervention. This tool can potentially prevent the progression from psoriasis to PsA by...
The model demonstrates good performance, which can be adjusted based on its intended use, such as screening or targeting high-risk individuals for intervention. This tool can potentially prevent the progression from psoriasis to PsA by...
The model demonstrates good...
10/24/2023
First Report Managed Care
News
Analyzing FDA Data on Just-in-Time Interventions, Digital Therapeutics
10/24/2023
The systematic review suggests that the available information in FDA databases regarding the performance and effectiveness of digital medical devices used in JITIs is quite diverse and often lacks comprehensive details, such as product...
The systematic review suggests that the available information in FDA databases regarding the performance and effectiveness of digital medical devices used in JITIs is quite diverse and often lacks comprehensive details, such as product...
The systematic review suggests...
10/24/2023
First Report Managed Care
News
Few Medicare Providers Offer Intensive Behavioral Therapy for Obesity
10/23/2023
Just 1% of primary care providers who cared for Medicare beneficiaries provided intensive behavioral therapy (IBT) for obesity at any time between 2013 and 2019, according to a study published online in PLOS One.
Just 1% of primary care providers who cared for Medicare beneficiaries provided intensive behavioral therapy (IBT) for obesity at any time between 2013 and 2019, according to a study published online in PLOS One.
Just 1% of primary care...
10/23/2023
First Report Managed Care

Behind the Bill

Behind the Bill
The Nondelegation Doctrine: The Next Constitutional Showdown (Part 1)
02/12/2025
Just when you thought the dust had settled from the Chevron decision, the Supreme Court is gearing up to hear arguments in Federal Communications Commission v Consumers' Research next month, potentially reviving the long-dormant nondelegation...
Just when you thought the dust had settled from the Chevron decision, the Supreme Court is gearing up to hear arguments in Federal Communications Commission v Consumers' Research next month, potentially reviving the long-dormant nondelegation...
Just when you thought the dust...
02/12/2025
First Report Managed Care
Behind the Bill
No, President Trump Did Not Actually Sign an Executive Order That Would Increase Drug Costs for Beneficiaries
02/05/2025
On inauguration day, President Trump issued an executive order rescinding several Biden-era health care initiatives, including 3 experimental drug pricing models developed by the Center for Medicare and Medicaid Innovation (CMMI). Oh boy did...
On inauguration day, President Trump issued an executive order rescinding several Biden-era health care initiatives, including 3 experimental drug pricing models developed by the Center for Medicare and Medicaid Innovation (CMMI). Oh boy did...
On inauguration day, President...
02/05/2025
First Report Managed Care
Behind the Bill
Robert F. Kennedy Jr’s Confirmation and the Unexpected Turn in the Drug Pricing Debate
01/29/2025
The Plot Thickens in Drug Pricing Drama Just when you thought the drug pricing debate couldn't get more interesting, Robert F. Kennedy Jr adds an unexpected twist. During closed-door Senate meetings, President Trump’s US Department of...
The Plot Thickens in Drug Pricing Drama Just when you thought the drug pricing debate couldn't get more interesting, Robert F. Kennedy Jr adds an unexpected twist. During closed-door Senate meetings, President Trump’s US Department of...
The Plot Thickens in Drug...
01/29/2025
First Report Managed Care
Behind the Bill
Medicare Drug Negotiations 2.0: New Administration, Same Mission?
01/22/2025
Last week brought 2 major developments in health care policy: President Trump's inauguration and the Centers for Medicare and Medicaid Services’ (CMS) announcement of 15 additional drugs selected for Medicare price negotiations. While these...
Last week brought 2 major developments in health care policy: President Trump's inauguration and the Centers for Medicare and Medicaid Services’ (CMS) announcement of 15 additional drugs selected for Medicare price negotiations. While these...
Last week brought 2 major...
01/22/2025
First Report Managed Care
Behind the Bill
The First 100 Days: Health Care's Critical Deadlines in 2025
01/15/2025
The 119th Congress faces immediate health care deadlines amid significant leadership transitions. While much attention focuses on high-profile nominations like Dr Oz for Centers for Medicare and Medicaid Services (CMS) Administrator and...
The 119th Congress faces immediate health care deadlines amid significant leadership transitions. While much attention focuses on high-profile nominations like Dr Oz for Centers for Medicare and Medicaid Services (CMS) Administrator and...
The 119th Congress faces...
01/15/2025
First Report Managed Care
Behind the Bill
Trump's Executive Orders in a Post-Chevron World: Implications for Health Care Policy
01/08/2025
Happy New Year! As we dive into 2025, it’s clear that this year promises to bring significant changes to health care. With President-elect Donald Trump's inauguration just weeks away, the spotlight is already shifting to how his...
Happy New Year! As we dive into 2025, it’s clear that this year promises to bring significant changes to health care. With President-elect Donald Trump's inauguration just weeks away, the spotlight is already shifting to how his...
Happy New Year! As we dive into...
01/08/2025
First Report Managed Care
Behind the Bill
A Tale of Two Congresses—Health Care Policy in the 117th vs 118th
12/18/2024
The 118th Congress is wrapping up with a whimper rather than a bang when it comes to health care legislation, particularly compared to its predecessor's transformative impact on pharmaceutical policy. As we reflect on these past 4 years, the...
The 118th Congress is wrapping up with a whimper rather than a bang when it comes to health care legislation, particularly compared to its predecessor's transformative impact on pharmaceutical policy. As we reflect on these past 4 years, the...
The 118th Congress is wrapping...
12/18/2024
First Report Managed Care
Behind the Bill
Medicare Privatization Under New CMS Leadership: What's Really at Stake
12/11/2024
After writing about Dr Oz's potential impact on Medicare drug negotiations last week, I found myself diving deeper into an aspect of his nomination that deserves closer attention: his vision for Medicare's future. A letter from Senate...
After writing about Dr Oz's potential impact on Medicare drug negotiations last week, I found myself diving deeper into an aspect of his nomination that deserves closer attention: his vision for Medicare's future. A letter from Senate...
After writing about Dr Oz's...
12/11/2024
First Report Managed Care
Behind the Bill
Medicare Drug Negotiations Under New CMS Leadership
12/04/2024
President-elect Donald Trump nominated Dr Mehmet Oz to lead the Centers for Medicare & Medicaid Services (CMS). With this potential change in leadership, are there any implications for Medicare’s drug price negotiation program,...
President-elect Donald Trump nominated Dr Mehmet Oz to lead the Centers for Medicare & Medicaid Services (CMS). With this potential change in leadership, are there any implications for Medicare’s drug price negotiation program,...
President-elect Donald Trump...
12/04/2024
First Report Managed Care
Behind the Bill

When Recess Isn’t a Break: What NLRB v Canning Means for HHS
11/20/2024
As Robert F. Kennedy Jr’s nomination for Secretary of Health and Human Services (HHS) moves through the Senate, there’s growing discussion about whether a recess appointment could be used to bypass confirmation challenges. The Supreme Court’s...
As Robert F. Kennedy Jr’s nomination for Secretary of Health and Human Services (HHS) moves through the Senate, there’s growing discussion about whether a recess appointment could be used to bypass confirmation challenges. The Supreme Court’s...
As Robert F. Kennedy Jr’s...
11/20/2024
First Report Managed Care

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