AHA 2022: Milestone Pharmaceuticals Announces Late-Breaking Presentation of Data From Phase 3 RAPID Clinical Trial of Etripamil Nasal Spray in Patients With Paroxysmal Supraventricular Tachycardia

MONTREAL and CHARLOTTE, N.C., Oct. 25, 2022 /-- Milestone Pharmaceuticals Inc., a biopharmaceutical company focused on the development and commercialization of innovative cardiovascular medicines, today announced that data from the Phase 3 RAPID clinical trial of self-administered etripamil in patients with paroxysmal supraventricular tachycardia (PSVT) in the at-home setting will be featured during a Late-Breaking Clinical Trials session at the American Heart Association Scientific Sessions 2022, taking place November 5-7, 2022 in Chicago, IL, and virtually. Etripamil, a new chemical entity, is Milestone's lead investigational product.

The Late-Breaker presentation details are:

Title: Self-Administered Etripamil for the Termination of Spontaneous Paroxysmal Supraventricular Tachycardia: Primary Analysis From the RAPID Study
Presentation number: 19625
Session number: LBS.08
Session Title: Late-Breaking Science: Treating Atrial and Supraventricular Arrhythmias
Presenter: James Ip, M.D., Associate Professor and Director of Cardiac Pacing and Implantable Devices, Division of Cardiology, Weill Cornell Medicine, New York Presbyterian Hospital, on behalf of Bruce Stambler, M.D., F.H.R.S, Director of Cardiac Arrhythmia Research and Education, Piedmont Heart Institute, Atlanta, GA and all co-authors.
Date and Time: Monday, November 7, 2022 from 11:13-11:23 a.m. CT

In addition, data from the previously completed Phase 3 NODE-301 trial will be featured in a poster presentation session, the details of which are:

Title: Patient-Reported Treatment Satisfaction in Etripamil-Mediated Conversion of Supraventricular Tachycardia to Sinus Rhythm: Results From the NODE-301 Study
Presentation Number: MO4023
Session Title: Benefits and Risks Associated with Arrhythmia Management
Presenter: James Ip, M.D., Associate Professor and Director of Cardiac Pacing and Implantable Devices, Division of Cardiology, Weill Cornell Medicine, New York Presbyterian Hospital, on behalf of all co-authors.
Date and Time: Monday, November 7, 2022 from 11:00 a.m.-12:00 p.m. CT

About Paroxysmal Supraventricular Tachycardia

Paroxysmal supraventricular tachycardia (PSVT) is a condition affecting approximately two million Americans that is characterized by intermittent episodes of a rapid heartbeat that starts and stops suddenly. Episodes of supraventricular tachycardia (SVT) are often associated with symptoms such as palpitations, sweating, chest pressure or pain, shortness of breath, sudden onset of fatigue, lightheadedness or dizziness, fainting, and anxiety. Certain intravenous medications, including adenosine, beta-blockers and calcium channel blockers, have long been used for the acute treatment of PSVT. However, these medications must be administered under medical supervision, usually in an emergency department or other acute care setting.

About Etripamil

Etripamil, a new chemical entity, is Milestone's lead investigational product. It is a novel calcium channel blocker designed to be a rapid-response therapy for episodic cardiovascular conditions. As a nasal spray that is self-administered by the patient, etripamil has the potential to shift the current treatment experience for many patients from the emergency department to a medically unsupervised setting. Milestone is conducting a comprehensive development program for etripamil, with Phase 3 trials ongoing in paroxysmal supraventricular tachycardia (PSVT) and a Phase 2 proof-of-concept trial that is underway in patients with atrial fibrillation with rapid ventricular rate (AFib-RVR).

About Milestone Pharmaceuticals

Milestone Pharmaceuticals Inc. (Nasdaq: MIST) is a biopharmaceutical company focused on the development and commercialization of innovative cardiovascular medicines. Milestone's lead product candidate etripamil is currently in a Phase 3 clinical-stage program for the treatment of paroxysmal supraventricular tachycardia (PSVT) and in a Phase 2 proof-of-concept trial for the treatment of patients with atrial fibrillation with rapid ventricular rate (AFib-RVR). Milestone Pharmaceuticals operates in Canada and the United States. For more information, visit www.milestonepharma.com and follow Milestone on Twitter at @MilestonePharma.